Figure 4. The increased/decreased usage of T cell receptor
(TCR)-Vβ families in CD4+CD25− T
cells and
CD4+CD25+CD127lowT cells of patients with autoimmune neutropenia (AIN) and control
subjects
Means and standard deviations (SDs) of TCR-Vβ family usage of
conventional T cells (CD4+CD25− T
cells) and regulatory T cells
(CD4+CD25+CD127lowT cells) were calculated in the control group and used as normal values.
Heat map classifies the degrees of each usage of TCR-Vβ families using
five colors; within normal range: −2 SD – +2 SD (white), >
+2 SD (pink), > +3 SD (red), < −2 SD (pale
green), < −3 SD (green) (a). The increased and decreased
numbers of CD4+CD25− T cell and
CD4+CD25+CD127lowT cells per person were compared. Data are represented as box-plots (b).
*p = 0.0022, **p = 0.0001 (Wilcoxon rank-sum test). n.s;
not significant.