Pharmacogenetics
DNA was collected from 32 patients and a total of 795 SNPs (8 forCYP3A4 , 7 for CYP3A5 , 16 for SULT2A1 , 110 forABCB1 , 85 for ABCG2 , 179 for ABCC1 and 390 forABCC4 ) were extracted from the array. Significant associations between genotypes and palbociclib Cmax and AUC0-Tlast following single (N=32) and repeated (N=24) doses are reported in Supplementary Tables S1-4 andFigures S2-5 . The frequency of significant SNPs is reported inSupplementary Table S5 . Multiples associations were found between palbociclib pharmacokinetic variables and SNPs fromSULT2A1 , ABCB1 , ABCG2 , ABCC1 , andABCC4 ; however, no associations were found with SNPs fromCYP3A4 and CYP3A5 genes.