Covariates
Treatment exposures (e.g. individual chemotherapeutic agents and
radiation) known to increase the risk of chronic health conditions in
survivors were selected a priori and informed by Children’s
Oncology Group guidelines version 5.0.26 Specific
treatment exposures were selected for each health outcome in order to
provide adequate adjustment for treatment exposures in separate models
(see Table 1 for a description of treatment exposures included for each
health outcome). Age at evaluation, age at cancer diagnosis, sex,
race/ethnicity, body mass index (BMI) and physical inactivity were
included as covariates in all models. Physical inactivity was defined as
not meeting Centers for Disease Control recommendation for physical
activity (75 minutes of vigorous or 150 minutes of moderate activity per
week).27 Weekly moderate and vigorous activities were
converted into metabolic equivalents (METS), individuals who reported
<450 METS per week were classified as inactive. Age at
evaluation, BMI and physical activity were assessed at the time of the
sleep survey.