2.4 Transcriptional profiles
To characterize the expression patterns of SARS-CoV-2 receptors in the heart, single-cell RNA sequencing (scRNA-seq) of 9,791 cells isolated from 12 normal human hearts was performing. The scRNA-seq data were obtained from the Gene Expression Omnibus (GEO) database with the accession number GSE109816 (Wang et al., 2020b) and processed using theSeurat toolkit (Butler, Hoffman, Smibert, Papalexi & Satija, 2018). The expression profile of peripheral blood from 93 CAD patients and 48 healthy individuals was analyzed using the Agilent-067406 Human Microarray V4.0 platform (Aglient, Santa Clara, USA), and the data were downloaded from the GEO database with the accession number GSE113079 (Li et al., 2018).