Pharmacokinetic analyses
Pharmacokinetic parameters derived from serum sample concentrations were calculated using a noncompartmental analysis (NCA). (NCA). The NCA was performed using R version 3.5.3 (22) while the linear trapezoid rule was used for the calculation of AUCs. Analysis of the differences between methods were based on least squares means from the ANOVA of the ln-transformed AUC0-t AUC0-inf, and Cmax. In addition, Wilcoxons tests were performed on Tmax.