Table 1: Clinical features of coagulopathy with various vascular anomalies
Features KMP KLA MLT Congenital Hemangioma LIC
Platelets ↓↓↓ ↓↓↓ ↓↓ - ↓↓↓ ↔ - ↓↓
Fibrinogen ↓ - ↓↓ ↓ - ↓↓ ↔ - ↓ ↔ - ↓↓
D-dimer ↑ - ↑↑ ↑ - ↑↑ ↔ - ↑ ↑↑ - ↑↑↑
Other distinguishing features Enlarges after birth; infiltrative Involves multiple sites and organs Lungs, skin and GI tract primarily Does not enlarge after birth; may involute rapidly Worsens with manipulation of malformation; pain and/or palpable phleboliths; at risk for VTE
Bleeding risk Minimal High High Minimal High with procedures