mAb solution (11 mg/mL) with no aggregate spike
Aggregate-spiked Ab solution (11 mg/mL); mAb (15 mg/mL) spiked at 1.0% with mAb aggregate (11.4% dimer and 33.3% trimer or larger species) prepared for application to column chromatography and nylon prefilter and adjusted to 11 mg/mL for analysis and virus filtration
Table 2 Dimer and trimer or larger species content of aggregate-spiked plasma IgG solutions used in the virus filtration process.