Drug-Drug Interactions, Adverse Reactions & Contraindications
As per the U.S FDA, the antacid Maalox TC (magnesium and aluminium hydroxide) when taken concomitantly reduces the absorption of Mycophenolate Mofetil. it also reduces the area under the curve (AUC). Moreover, a variation of the drug concentration in blood plasma over a period of time also reduces the maximum serum concentration of the drug (Cmax). All the above conditions are compared when MMF is taken orally while fasting. In addition, persons who use MMF are at increased risk of infections, including progressive multifocal leukoencephalitis (PML) and opportunistic infection among renal, cardiac and hepatic transplant patients. The use of MMF is contraindicated during pregnancy as it can cause congenital malformations and miscarriages [15].