Pharmaceutical Properties
Cyclosporine is an immunosuppressive drug which has shown remarkable success in kidney, liver, heart allogeneic transplant. It suppresses humoral immunity to a greater extent along with delayed hypersensitivity, allograft rejection due to cell mediation and allergic encephalopathy. \soutAs per the U.S FDA, It is reported that 90% of cyclosporine is bound to lipoprotein in blood, but largely it is distributed outside the blood volume. The uptake of cyclosporine are as follows : erythrocytes (41-58%), plasma (33-47%), granulocytes (5-12%) and lymphocytes (4-9%), while in leukocytes and erythrocytes, it saturates at higher concentrations [24-25].