Pharmaceutical Properties
Enbrel is the brand name of Etanercept which has a wide range of usage
in terms of reducing signs and symptoms for polyarticular juvenile
idiopathic arthritis, rheumatoid arthritis, ankylosing spondylitis,
psoriatic arthritis, plaque psoriasis etc. Enbrel can be presented in
the form of a 25mg multiple use vial which appears as a white sterile
lyophilized powder containing inactive ingredients like 10mg sucrose,
40mg mannitol and 1.2mg tromethamine with pH varying from 7.1 to 7.7. It
can also be presented as a 25mg/50mg prefilled syringe which contains
inactive ingredients like 25mM L-arginine hydrochloride, sodium
phosphate, 1% sucrose and 100mM sodium chloride. It appears clear,
colorless and sterile with pH varying from 6.1 to 6.5. Enbrel is linked
to the Fc (fragment crystallizable) portion of human IgG1
(immunoglobulin G) through the tumor necrosis factor receptor (TNFR).
Enbrel is a dimeric fusion protein which consists of a human 75
kilodalton (p75) extracellular ligand binding portion [10-12].