Drug-Drug Interactions, Adverse Reactions & Contraindications
Enbrel is not recommended for patients taking cyclophosphamide, especially for those suffering from Wegener granulomatosis as it can cause a higher incidence of solid malignancies. Similarly, Enbrel is not recommended with Sulfasalazine as it can lead to reduction of neutrophil count. Enbrel should be given to patients with live vaccines specifically varicella viruses, but it can be considered for prophylactic treatment as well. Based on clinical trials, Enbrel can cause adverse reactions for patients with plaque psoriasis, ankylosing spondylitis, rheumatoid arthritis, psoriatic arthritis, etc. [13]. In terms of contraindication, Enbrel should not be administered to patients with sepsis.