Pharmaceutical Properties
Cyclosporine is an immunosuppressive drug which has shown remarkable
success in kidney, liver, heart allogeneic transplant. It suppresses
humoral immunity to a greater extent along with delayed
hypersensitivity, allograft rejection due to cell mediation and allergic
encephalopathy. \soutAs per the U.S FDA, It is reported that 90% of
cyclosporine is bound to lipoprotein in blood, but largely it is
distributed outside the blood volume. The uptake of cyclosporine are as
follows : erythrocytes (41-58%), plasma (33-47%), granulocytes
(5-12%) and lymphocytes (4-9%), while in leukocytes and erythrocytes,
it saturates at higher concentrations [24-25].