Methicillin-Resistant Staphylococcus Aureus Group (N=48)
The mean age of the patients at first isolation of MRSA was 7.66 ± 5.71 years. The mean duration from diagnosis to first MRSA isolation was 6.3 ± 5.25 years. While 17 isolations (35.4%) were successfully eradicated at 1 year, 17 patients (35.4%) had intermittent and 14 (29.2%) had chronic infection (Table 2).
The most common MRSA eradication regimen used in our clinic was intravenous teicoplanin for 14 days. The highest success rate among treatments was 14 days oral Trimethoprim / Sulfamethoxazole (TMP/SMX) + Rifampicin by 50% eradication success. Statistical analysis did not show any difference between treatment regimens (p > 0.05). Additionally, successful eradication rates were not significantly different between intravenous and oral treatment groups (p = 0.57).
Sex, diagnosis age, age at isolation, BMI z-score, ΔF508 mutation, pancreatic insufficiency, CFRD, biliary-hepatic disease, dornase alfa use, inhaled corticosteroid use, ABPA, hospitalization rate in the preceding year and FEV1pp were not statistically significant as a predictor (p > 0.05).
20 out of 48 patients were able to perform spirometry. The mean FEV1pp of patients in eradicated and not eradicated groups were 88.9 ± 21and 93.2 ± 13.1, respectively (p > 0.05).