Background:
Chronic benign neutropenia (CBN) and autoimmune neutropenia (AIN) are notoriously difficult to differentiate in children owing to their indistinguishable clinical course and varying availability and accuracy in the methods of anti-neutrophil antibody detection. This study aims to investigate whether the presence of anti-neutrophil antibody has implications on the disease course in Chinese children with AIN, as well as evaluating the various methods including LABScreen MULTI, granulocyte agglutination test (GAT) and granulocyte immunofluorescence test (GIFT) in anti-neutrophil antibody detection.