Background:
Chronic benign neutropenia (CBN) and autoimmune neutropenia (AIN) are
notoriously difficult to differentiate in children owing to their
indistinguishable clinical course and varying availability and accuracy
in the methods of anti-neutrophil antibody detection. This study aims to
investigate whether the presence of anti-neutrophil antibody has
implications on the disease course in Chinese children with AIN, as well
as evaluating the various methods including LABScreen MULTI, granulocyte
agglutination test (GAT) and granulocyte immunofluorescence test (GIFT)
in anti-neutrophil antibody detection.