Statistical methods.
Continuous variables are shown as Mean ± SD or as Median [IQR] as appropriate, while discrete variable as n(%). Comparison of continuous variables was preformed using Mann-Whitney U test, while comparison of discrete variables using Fisher’s exact test. Event free survival was assed using Kaplan-Mayer curves, statistical significance of the difference between curves was assessed using a log-rank test. Results were considered significant when p<0.05. All calculations were done using R version 3.5.0, R Foundation for Statistical Computing, Vienna, Austria.