Transthoracic echocardiography was performed on mice at the end of the animal study. EF, ejection fraction %, FS, fractional shortening %; LVIDd, diastole left ventricle internal dimension; PWd, diastole posterior wall thickness; IVSd, diastole interventricular septal thickness; E wave; IRT, isovolumic relaxation time; Tei index; Data are presented as the mean ± SEM, n = 7. * p < 0.05 compared to ctrl; # p < 0.05 compared to Ang II; ns = not significant.