Abbreviations
ALT, alanine transaminase; ANIT, α-naphthylisothiocyanate; AP, alkaline phosphatase;AST, aspartate transaminase; ATP,adenosine triphosphate ; BDL, bile duct ligation; BMDMs, bone marrow-derived macrophages; Bsep, bile salt export pump; CCR-2, C–C chemokine receptor type-2; CLD, cholestatic liver disease; DDC, 3,5-diethoxycarbonyl-1,4-dihydrocollidine; FXR, farnesoid X receptor; γ-GT, γ-glutamyltransferase; IL-1β, interleukin 1 beta; KCs, Kupffer cells; LPS, lipopolysaccharide; LXR, liver X receptor; MCP, monocyte chemoattractant protein; NFκb, nuclear factor κB; OCA, obeticholic acid; PBC, primary biliary cholangitis; PPARγ, peroxisome proliferator-activated receptor-γ; PSC, primary sclerosing cholangitis; TBA, total bile acids; TCMs, traditional chinese medicines; TEC, tectorigenin; TZDs,thiazolidinedione compounds; UDCA, ursodeoxycholic acid.
Acknowledgments
This work was supported by grants from Natural Science Foundation of Tianjin (19JCQNJC12600); Research project of Tianjin education commission (2019KJ044).