Metabolic pathway of differential metabolites
Function of the pathways associated with differential metabolites
analysis by Kyoto Encyclopedia of Genes and Genomes (KEGG) was used to
understand how multiple pathways altered in response to treat with APEC
and BAI in the present study. As shown in Fig. 9A, Phenylalanine
metabolism; Phenylalanine, tyrosine and tryptophan biosynthesis;
Cysteine and methionine metabolism; Riboflavin metabolism; Tryptophan
metabolism; Alanine, aspartate and glutamate metabolism were enriched in
the gut of the APEC group chicken compared to the CON group, while in
addition to Alanine, aspartate and glutamate metabolism, the D-Glutamine
and D-glutamate metabolism; Caffeine metabolism, Lysine biosynthesis;
Histidine metabolism; Arginine and proline metabolism; TCA cycle;
Retinol metabolism; and alpha-Linolenic acid metabolism were enriched in
BAI+APEC group compared to the APEC group chickens (Fig. 9B). In
addition, Ubiquinone and other terpenoid-quinone biosynthsis; Linoleic
acid metabolism; Caffeine metabolism; Riboflavin metabolism; Alanine,
aspartate and glutamate metabolism; Histidine metabolism; Glycine,
serine and threonine metabolism; Cysteine and methionine metabolism; and
alpha-Linolenic acid metabolism were enriched in the gut of the BAI
group compared to the CON group chickens (Fig. 9C).