KEY RESULTS
Depletion of gut microbiota exacerbated the tissue damage and weakened
the protective effects of baicalin during APEC-induced chicken
colibacillosis while pretreatment of baicalin reduced these changes and
inflammatory response induced by APEC. Moreover, APEC infection led to
dysbiosis of gut microbiota and its metabolites. However, the
pretreatment of baicalin remodeled the gut microbiota featured with
increased abundance of Intestinimonas and its associated with beneficial
metabolites.