Animals
Sixty male Swiss albino rats weighing (150-200) g were used. The animals were housed in the animal facility of the Faculty of Medicine, Ain Shams University. The rats were kept under standard conditions of temperature (21°C ± 0.5) and relative humidity (55 ± 1) with 12-light/12-dark cycle. They were fed with standard diet pellets (El-Nasr Chemical Company, Abou-Zaabal, Cairo, Egypt). Food and water were given ad libitum.The experimental protocol utilized in this examination was endorsed by the Animal Ethics Committee (No. 70/2016) of the Faculty of Pharmacy, Al-Azhar University, Egypt.