Conclusion
Based on these broad observations, one could argue that both
nutraceuticals tested in the current study have improved the
spermatogenic and steroidogenic functions in male rats. Though one
cannot unravel the exact mechanism(s) whereby both natural drugs have
exerted their beneficial actions, however their anti-oxidant and
anti-inflammatory effects observed in the present work maybe one of the
culprits behind this issue. Besides, their unique up-regulatory effects
on occludin expression in testicular tissue could possibly account to
their protective effects on gonadal tissue as they restored the
integrity of the basement membrane whose complex network structure
compiles many of the junctional proteins and adherence molecules and
other adaptor proteins. So, by restoring the tight junction integrity
the blood testes barrier acts once again as a defense mechanism against
various xenobiotics such as acrylamide.