Usefulness of LTE4 in predicting development of DHF in early illness
As urinary LTE4 levels were higher in patients who proceeded to develop DHF during early illness (≤ 4 days of illness), we sought to assess if urinary LTE4 could be used as a predictive marker of subsequent development of DHF in early illness. Receiver-operator characteristic (ROC) curves showing the area under the curve (AUC) were generated to determine the discriminatory performance of LTE4 for DHF in early illness, which showed an AUC value of 0.67, with a 95% confidence interval of 0.57 and 0.76, which was significant (p=0.002)(Figure 3) .