Experimental Approach
We used heterozygous SERCA2 C674S knock-in (SKI) mice, where half of
C674 was substituted by serine, to represent partial irreversible
oxidation of C674. The aortas of SKI mice and their littermate wild-type
mice were collected for RNA sequencing, cell culture, protein
expression, luciferase activity and aortic aneurysm analysis.