Background and Purpose
Inactivation of Cys674 (C674) in the
sarcoplasmic/endoplasmic reticulum Ca2+ ATPase 2
(SERCA2) by causing the accumulation of intracellular
Ca2+ to activate calcineurin-mediated nuclear factor
of activated T-lymphocytes (NFAT)/NF-κB pathways, resulted in the
phenotypic modulation of smooth muscle cells (SMCs) to accelerate
angiotensin II-induced aortic aneurysm. Our goal was to investigate the
mechanism involved.