‘Clinical significance’
- Increase levels of ROS irreversibly oxidize Cys674in SERCA2 to promote the development of aortic aneurysm by suppressing
PPARγ.
- Activating PPARγ contributes to controlling aortic aneurysm by
restricting SMC phenotypic modulation.
- PPARγ and SERCA2 may be potential therapeutic targets for aortic
aneurysm.