Conclusions
Implications for practice: Acquired PE subjects and PE sufferers who have accompanying erectile dysfunction and/or anxiety may benefit from thyroid disorder investigation. Screening men for thyroid disease may also be useful in patients with DE.
Implications for research: With current knowledge of available studies, we are still far from establishing any conclusion on a causal relationship between EjD and thyroid disorders. Available evidence suggests Dopaminergic pathways in the central nervous system that mediates the emission phase of the ejaculation might be a good research area for experimental studies that aimed to clarify the interrelation between thyroid disorder and ejaculatory dysfunction in men. Further longitudinal studies with a good sample size estimation based on the population-based prevalence rates of thyroid disorders, using standardized diagnostic tools (PRO related to ejaculation, measured IELT, etc.) and an appropriate length of follow–up evaluations may enhance the quality of scientific evidence on this emerging topic.