Results
Out of the identified 452 studies, 27 studies were eligible for
inclusion. The pooled analyses showed non-significant associations
between ACEIs/ARBs and death (OR:0.97, 95%CI:0.75,1.27), ICU admission
(OR:1.09;95%CI:0.65,1.81), death/ICU admission (OR:0.67;
95%CI:0.52,0.86), risk of COVID-19 infection (OR:1.01;
95%CI:0.93,1.10), severe infection (OR:0.78; 95%CI:0.53,1.15) and
hospitalisation (OR:1.15; 95%CI:0.81,1.65). However, the sub-group
analyses indicated different results such as significant association
between ACEIs/ARBs and hospitalisation among USA studies (OR:1.59;
95%CI:1.03,2.44), peer-reviewed (OR:1.93, 95%CI:1.38,2.71), good
quality and studies which reported adjusted measure of effect (OR:1.30,
95%CI:1.10,1.50). Significant differences were found between ACEIs and
ARBs with the latter being significantly associated with lower risk of
acquiring COVID-19 infection (OR:0.24; 95%CI: 0.17,0.34).