Author contributions

M.P.O conceptualized the research, researched data, wrote and edited the manuscript. S.D.A validated data research and reviewed the manuscript. C.C.M.S-V conceptualized methods and reviewed the manuscript, H.J.B validated data research and organized database. K.T conceptualized methods and reviewed the manuscript. E.H supervised the research and reviewed the manuscript. P.D conceptualized the research, supervised the research, reviewed and edited the manuscript.
1. Masnoon N, Shakib S, Kalisch-Ellett L, Caughey GE. What is polypharmacy? A systematic review of definitions. BMC Geriatr . 2017;17(1):230-017-0621-2.
2. Oktora MP, Denig P, Bos JHJ, Schuiling-Veninga CCM, Hak E. Trends in polypharmacy and dispensed drugs among adults in the netherlands as compared to the united states. PLoS One . 2019;14(3):e0214240.
3. Guthrie B, Makubate B, Hernandez-Santiago V, Dreischulte T. The rising tide of polypharmacy and drug-drug interactions: Population database analysis 1995-2010. BMC Med . 2015;13:74-015-0322-7.
4. Moriarty F, Hardy C, Bennett K, Smith SM, Fahey T. Trends and interaction of polypharmacy and potentially inappropriate prescribing in primary care over 15 years in ireland: A repeated cross-sectional study.BMJ Open . 2015;5(9):e008656-2015-008656.
5. Bauer S, Nauck MA. Polypharmacy in people with type 1 and type 2 diabetes is justified by current guidelines–a comprehensive assessment of drug prescriptions in patients needing inpatient treatment for diabetes-associated problems. Diabet Med . 2014;31(9):1078-1085.
6. Payne RA, Abel GA, Avery AJ, Mercer SW, Roland MO. Is polypharmacy always hazardous? A retrospective cohort analysis using linked electronic health records from primary and secondary care. Br J Clin Pharmacol . 2014;77(6):1073-1082.
7. Veehof L, Stewart R, Haaijer-Ruskamp F, Jong BM. The development of polypharmacy. A longitudinal study. Fam Pract . 2000;17(3):261-267.
8. Alwhaibi M, Balkhi B, Alhawassi TM, et al. Polypharmacy among patients with diabetes: A cross-sectional retrospective study in a tertiary hospital in saudi arabia. BMJ Open . 2018;8(5):e020852-2017-020852.
9. Tommelein E, Mehuys E, Petrovic M, Somers A, Colin P, Boussery K. Potentially inappropriate prescribing in community-dwelling older people across europe: A systematic literature review. Eur J Clin Pharmacol . 2015;71(12):1415-1427.
10. Formiga F, Vidal X, Agusti A, et al. Inappropriate prescribing in elderly people with diabetes admitted to hospital. Diabet Med . 2016;33(5):655-662.
11. Al Khaja KAJ, Ahmed Isa H, Veeramuthu S, Sequeira RP. Potentially inappropriate prescribing in older adults with hypertension or diabetes mellitus and hypertension in a primary care setting in bahrain.Med Princ Pract . 2018;27(3):241-249.
12. U.S Department of Health and Human Service, Centers for Disease Control and Prevention (CDC). National diabetes statistics report 2020. estimates of diabetes and its burden in the united states. . 2020:2.
13. Visser ST, Schuiling-Veninga CC, Bos JH, de Jong-van den Berg LT, Postma MJ. The population-based prescription database IADB.nl: Its development, usefulness in outcomes research and challenges.Expert Rev Pharmacoecon Outcomes Res . 2013;13(3):285-292.
14. Sediq R, van der Schans J, Dotinga A, et al. Concordance assessment of self-reported medication use in the netherlands three-generation lifelines cohort study with the pharmacy database iaDB.nl: The PharmLines initiative. Clin Epidemiol . 2018;10:981-989.
15. Nederlands Huisartsen Genootschap (NHG), Nederlandse Vereniging voor Klinische Geriatrie (NVKG), Orde van Medisch Specialisten (OMS). Multidisciplinaire richtlijn polyfarmacie bij ouderen 2012. https://www.nhg.org/sites/default/files/content/nhg_org/uploads/polyfarmacie_bij_ouderen.pdf. Updated 2012. Accessed December 16, 2019.
16. By the American Geriatrics Society 2015 Beers Criteria Update Expert Panel. American geriatrics society 2015 updated beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc . 2015;63(11):2227-2246.
17. Cooper JA, Ryan C, Smith SM, et al. The development of the PROMPT (PRescribing optimally in middle-aged people’s treatments) criteria.BMC Health Serv Res . 2014;14:484-014-0484-6.
18. Dobrica EC, Gaman MA, Cozma MA, Bratu OG, Pantea Stoian A, Diaconu CC. Polypharmacy in type 2 diabetes mellitus: Insights from an internal medicine department. Medicina (Kaunas) . 2019;55(8):10.3390/medicina55080436.
19. Noale M, Veronese N, Cavallo Perin P, et al. Polypharmacy in elderly patients with type 2 diabetes receiving oral antidiabetic treatment.Acta Diabetol . 2016;53(2):323-330.
20. Molokhia M, Majeed A. Current and future perspectives on the management of polypharmacy. BMC Fam Pract . 2017;18(1):70-017-0642-0.
21. Santos NSD, Marengo LL, Moraes FDS, Barberato Filho S. Interventions to reduce the prescription of inappropriate medicines in older patients.Rev Saude Publica . 2019;53:7-8787.2019053000781.
22. Bongue B, Naudin F, Laroche ML, et al. Trends of the potentially inappropriate medication consumption over 10 years in older adults in the east of france. Pharmacoepidemiol Drug Saf . 2009;18(12):1125-1133.
23. Jirón M, Pate V, Hanson LC, Lund JL, Jonsson Funk M, Stürmer T. Trends in prevalence and determinants of potentially inappropriate prescribing in the united states: 2007 to 2012. J Am Geriatr Soc . 2016;64(4):788-797.
24. Cooper JA, Moriarty F, Ryan C, et al. Potentially inappropriate prescribing in two populations with differing socio-economic profiles: A cross-sectional database study using the PROMPT criteria. Eur J Clin Pharmacol . 2016;72(5):583-591.
25. Moriarty F, Cahir C, Bennett K, Hughes CM, Kenny RA, Fahey T. Potentially inappropriate prescribing and its association with health outcomes in middle-aged people: A prospective cohort study in ireland.BMJ Open . 2017;7(10):e016562-2017-016562.
26. van der Hooft CS, Jong GW, Dieleman JP, et al. Inappropriate drug prescribing in older adults: The updated 2002 beers criteria–a population-based cohort study. Br J Clin Pharmacol . 2005;60(2):137-144.
27. Bickett A, Tapp H. Anxiety and diabetes: Innovative approaches to management in primary care. Exp Biol Med (Maywood) . 2016;241(15):1724-1731.
28. Ogilvie RP, Patel SR. The epidemiology of sleep and diabetes.Curr Diab Rep . 2018;18(10):82-018-1055-8.
29. Yang H, Juang SY, Liao KF. Proton pump inhibitors use and risk of chronic kidney disease in diabetic patients. Diabetes Res Clin Pract . 2019;147:67-75.
30. Ahmedzai SH, Boland J. Constipation in people prescribed opioids.BMJ Clin Evid . 2010;2010:2407.
31. Emmanuel A, Johnson M, McSkimming P, Dickerson S. Laxatives do not improve symptoms of opioid-induced constipation: Results of a patient survey. Pain Med . 2017;18(10):1932-1940.
32. Nederlands Huisartsen Genootschap (NHG). NHG-standaarden. https://www.nhg.org/nhg-standaarden. Updated 2019. Accessed 06/08, 2020.
33. Motter FR, Fritzen JS, Hilmer SN, Paniz EV, Paniz VMV. Potentially inappropriate medication in the elderly: A systematic review of validated explicit criteria. Eur J Clin Pharmacol . 2018;74(6):679-700.
34. Rieckert A, Reeves D, Altiner A, et al. Use of an electronic decision support tool to reduce polypharmacy in elderly people with chronic diseases: Cluster randomised controlled trial. BMJ . 2020;369:m1822.
35. Clyne B, Fitzgerald C, Quinlan A, et al. Interventions to address potentially inappropriate prescribing in community-dwelling older adults: A systematic review of randomized controlled trials. J Am Geriatr Soc . 2016;64(6):1210-1222.