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\begin{document}

\title{Effect of herbal compounds on inhibition of coronavirus; A systematic
review and meta-analysis}



\author[1]{Fatemeh Ramezani}%
\author[1]{Mina Mobini}%
\author[1]{Sara Shavandi}%
\author[1]{Niloofar Haeri moghaddam}%
\affil[1]{Iran University of Medical Sciences}%


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  \date{May 30, 2024}


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\begin{abstract}
The outbreak of the new coronavirus (COVID-19) has been transferred
exponentially. There are many articles that have found the inhibitory
effect of plant extracts or plant compounds on the coronavirus family.
In this study, we want to use systematic review and meta-analysis to
answer the question of which herbal compound can be more effective
against the coronavirus. The present study is based on the guidelines
for conducting meta-analyzes. An extensive search was conducted in the
electronic database, and based on the inclusion and exclusion criteria,
articles were selected and data screening was performed. Quality control
of articles was performed. Data analysis was carried out in STATA
software. The results showed that alkaloid compounds had a good effect
in controlling the coronavirus and reducing viral titer. Trypthantrin,
Sambucus extract, S. cusia extract, Boceprevir and Indigole B, dioica
agglutinin urtica had a good effect on reducing the virus titer but
their selectivity index has not been reported and it is recommended to
determine for these compounds. Also among the compounds that had the
greatest effect on virus inhibition, including Saikosaponins B2,
SaikosaponinsD, SaikosaponinsA and Phillyrin, had an acceptable
selectivity index greater than 10. Andrographolide showed the highest
selectivity index on SARS-COV2, while virus titration and virus
inhibition were not reported. The small number of studies that used
alkaloid compounds was one of the limitations and it is suggested to
investigate the effect of more alkaloid compounds against the
coronavirus for verifying its effect.%
\end{abstract}%



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