Abbreviations:
Leigh syndrome (LS), Cerebrospinal fluid (CSF), Magnetic resonance imaging (MRI), Magnetic resonance spectroscopy (MRS), Nicotinamide adenine dinucleotide hydrogen (NADH), Deep tendon reflex (DTR), Complete blood count (CBC), Electroencephalogram (EEG), Generalized tonic clonic (GTC), Lactate dehydrogenase (LDH), Anti-Neuromyelitis optica antibody (NMO-Ab), High performance liquid chromatography (HPLC), Anti nucleotide antibody (ANA), Anti- double stranded DNA (Anti-ds DNA), Anti-sjögren’s- syndrome- related antigen A (Anti-SSA-RO and SSA-LA), Rapid Plasma Reagin (RPR), Alpha fetoprotein (AFP), Anti-ganglioside antibody (anti-GM antibody), Serum Angiotensin converting enzyme (ACE), Human immunodeficiency virus (HIV), Venereal disease research laboratory test (VDRL), 2-mercaptoethanol Brucella agglutination test (2ME).