Limitations and Restrictions of AIT RWD Analyses
The results in real-world analyses summarized here have some limitations
and restrictions, e.g. the validity of disease diagnoses (in most
studies medication serves as a proxy to identify the disease) or the
influence of OTC medication which is not included in prescription
databases. Patients’ drug consumption behavior is not analyzed, the
severity of the disease and patients’ symptom control is not known. The
selection of control patients in the chosen matching process has a
strong impact on the results. A detailed overview is given in Table S10
in the supplementary information.