Conclusion:
  1. This case emphasizes that with the availability of novel agents (Daratumumab) and use of bortezomib, even refractory PBL could be treated successfully.
  2. This case signifies that daEPOCH followed by upfront autologous stem cell transplant in CR1 is a suitable option in primary PBL giving durable remission.
  3. To the best of our knowledge this is the first reported case of a relapsed HIV negative PBL treated with AlloHCT who is disease-free for more than 2 years.