Effects of sapropterin medication on the disease severity in EAE
mice
A: Time courses of the clinical EAE scores (median ± siqr),
body weights (mean ± SD), score frequency distribution and AUCs of score
of SJL/J mice in PLP-induced relapsing-remitting EAE. Mice were treated
orally with vehicle (2% DMSO), sapropterin (2 mg/d) or DAHP (4 mg/d) in
the drinking water starting at the day of immunization. The score
courses were analyzed using Friedmann statistics, the score frequency
distribution using the ChiSquare test and the AUCs of the scores were
compared with the Kruskal Wallis test (n = 6-8 per group).
B: Time courses of the clinical EAE scores, body weights, score
frequency distribution and AUCs of EAE scores in C57Bl6/J mice in
MOG-induced primary progressive EAE. Mice were treated orally with
vehicle or sapropterin soaked cornflakes once daily (dosages as in A).
The score courses were analyzed using Wilcoxon P statistics, the score
frequency distribution using the ChiSquare test and the AUCs of the
scores were compared with the Mann Whitney U test (n = 10 per group).
The box plots in A and B show the interquartile range, the line is the
median, whiskers show minimum to maximum, each scatter is a mouse.
Figure 3: