Fig 2. Mechanisms of action of tumour antigen-targeting antibodies
Tumour antigen-targeting (tumour-depleting) antibodies mediate tumour cell-killing via different mechanisms: (1,2) activation of immune effector cells (ADCC, ADCP), (3) initiation of complement cascade (CDC), (4) blocking important signalling pathways in tumour cells and (5) formation of immune complexes inducing enhanced tumour antigen cross-presentation by DCs, leading to adaptive immune response.