Results
Baseline Demographics
235 patients presented a positive OFC between January 2018 and December 2022: 143 suffered from anaphylaxis, according to the ICD-11 classification. The median age was 9 years both in the whole population and in the subgroup of patients with anaphylaxis.
45 patients (31.5%) in the anaphylaxis group already experienced anaphylaxis during their clinical history when exposed to the culprit food, while 16 (17.4%) had a history of initial anaphylaxis but did not experience anaphylaxis during the positive OFC (p-value< 0.02). Eighty-three (35.3%) had no initial medical history with the tested food, and, among them, 49 patients (59.0% of this group) reacted with anaphylaxis, constituting 34.3% of all anaphylaxis cases. 102 patients (71.3%) presented a more severe reaction during the OFC, if compared to the one recorded in their clinical history. This group includes 98 patients transitioning from grade 1 to anaphylaxis, and 4 transitioning from anaphylaxis to anaphylactic shock.