Effectiveness criteria: rate of patients without failure or
complication
In this cost-effectiveness analysis, the main criterion used to express
the effectiveness of the initial menorrhagia surgery was the rate of
patients without failure over time, for each surgical category. Using atime-to-event variable allowed considering both the proportion of
failures that occurred in each surgical group and their time of
occurrence. Failure (considered as the event) was defined as the
first re-hospitalization that occurred either as i) stay for new
bleeding surgery (Online supporting material 2 ), ii) stay
containing a menorrhagia CIM-10 code stated as main- or
related-diagnosis or iii) stay containing any CIM-10 codes for
pregnancy .
As a secondary endpoint, effectiveness of the initial AUB surgery was
also compared between strategies using the rate of patients without
severe complications over time. Severe complication was defined as the
first event that occurred either as 1) re-hospitalization during
the 30 days following the surgery due to anemia, shock, any complication
directly linked to the surgical intervention, pain, infection, blood
supply, inflammatory disorders or hemoperitoneum within urologic,
genital, abdominal or pelvic location or 2) re-hospitalization at
any time after the initial surgery due to adhesions, foreign body, pain,
ventral hernia, renal failure, intestinal obstruction or other digestive
disorders, urologic/genital disorders within urologic, genital,
abdominal or pelvic location.