Figure 2. Metabolite chromatogram.
The chromatograms show the (A) metabolites identified using pooled human
liver microsomes incubated with ivermectin for 60 min, (B) metabolites
identified in the media fraction of primary human hepatocytes exposed to
ivermectin for 24 hours, and (C) metabolites identified in human
volunteer blood 24 hours after ivermectin administration.
Figure 3. Extracted ion chromatogram and MS/MS spectra .
The figure shows (A) extracted ion chromatogram of ivermectin
B1a and B1b, (B) MS/MS spectrum of
ivermectin B1b, (C) MS/MS spectrum of ivermectin
B1a, and (D) major fragment pattern of ivermectin.