Figure 2. Metabolite chromatogram.
The chromatograms show the (A) metabolites identified using pooled human liver microsomes incubated with ivermectin for 60 min, (B) metabolites identified in the media fraction of primary human hepatocytes exposed to ivermectin for 24 hours, and (C) metabolites identified in human volunteer blood 24 hours after ivermectin administration.
Figure 3. Extracted ion chromatogram and MS/MS spectra .
The figure shows (A) extracted ion chromatogram of ivermectin B1a and B1b, (B) MS/MS spectrum of ivermectin B1b, (C) MS/MS spectrum of ivermectin B1a, and (D) major fragment pattern of ivermectin.