Supplementary
Figure S1: Figure S1: Comparison between the treatment groups in the mean change in the Hot Flush Scores over time from randomisation to week 12
Figure S2: Figure S2: Comparison between the treatment groups in the mean change in the domain scores of the Greene Climacteric Scale from randomisation to week 12
Figure S3: Figure S3: Comparison between the treatment groups in the mean change in the domain scores of the Utian Quality of Life Scale from randomisation to week 12
Table S1: Changes in Hot Flush Score B from randomisation - primary and secondary outcomes
Table S2: Changes in Greene Climacteric Scale and Utian Quality of Life Score from randomisation – secondary outcome measures
Table S3: Multilevel mixed-effects model fitted to weekly Hot Flush Score from randomisation to week 12 based on Sloan Diary Composite Score B
Table S4: Treatment effect from multilevel mixed-effects model fitted to all secondary outcomes
Table S5: Comparison of treatment groups as regards week 12 Folate levels
Table S6: Sensitivity analysis for primary outcome measure of change in daily Hot Flush Score at week 12 from randomisation from Sloan Diary composite score B
Table S7: Reported Adverse Events