CONS: BIOLOGICALS DO NOT PREVENT OR MODIFY PROGRESSION OF ALLERGIC DISEASES UPON DISCONTINUATION
A positive disease-modifying immunological effect would indicate that biologicals prevent the onset or the progression of the disease, the development of associated co-morbidities, support tolerance development by allergen immunotherapy (AIT) or create a persistent beneficial effect after cessation of the treatment.
In conclusion, there is no evidence that biologicals can sustainably break vicious cycles of inflammation and thereby rescind or stop the progression of the disease. Moreover, we do not have sufficient evidence to suggest a role of T2 immunity targeting biologicals to promote tolerance development to allergens when applied with or without AIT.