Clinical characteristic and laboratory abnormalities
Twenty-five consecutive pregnant women with COVID-19 confirmed by RT-PCR for SARS-CoV-2 are included in this analysis. Eleven cases (44.0%) were in the early and middle pregnancy group, and the remainder were in the late pregnancy group (Table 1). Seven (28.0%) had mild disease, 15 (60.0%) had moderate disease, and 3 (12.0%) had severe disease. The most common symptoms were fever (12/25, 48.0%) and cough (12/25, 48.0%), followed by sputum production (16.0%), dyspnea (8.0%), fatigue (4.0%), anorexia (4.0%), sore throat (4.0%), myalgia (4.0%) and diarrhea (4.0%). Seven (28.0%) were asymptomatic. Fever was more prevalent in early and middle pregnancy than in late pregnancy (72.7% vs. 28.6%, p=0.028), but not statistically in other symptoms of two groups (Table 1).
Data from laboratory tests showed that creatinine and D-Dimer was significantly lower in early and middle pregnancy than that in late pregnancy (40.0 umol/L vs. 48.0 umol/L, P= 0.033; 0.8 mg/L vs. 1.7 mg/L, P=0.038, respectively). Other laboratory findings, including leukocyte count, hemoglobin, albumin, globulin and alanine transaminase were similar between the two groups (Table 2).
All of the patients had chest X-ray or CT scan imaging on admission, the majority (60.0%) had bilateral abnormalities including ground-glass opacity or patchy shadowing, and the remainder had unilateral abnormalities. Radiographic presentations were similar in the early and middle pregnancy and late pregnancy groups (Table 2).