Treatment, Maternal complications and Pregnancy outcomes in late
pregnancy
Among 14 patients in late pregnancy, gestational age at diagnosis ranged
from 28 weeks to 39 weeks. Only one (7.1%) developed severe disease and
the others were moderate (57.1%) or mild type (35.7%). Hypothyroidism
was observed in patient 1, gestational diabetes mellitus (GDM) was
observed in patient 7 without use of corticosteroid and
pregnancy-induced hypertension (PIH) was showed in patient 14. All
patients received oxygen inhalation and antiviral
treatment(Arbidol/Ribavirin/Lianhua Qingwen/Oseltamivir). Systemic
glucocorticoids were used in 72.7% of patients and antibiotics were
used in 57.1% of patients. All had been discharged for recovered from
the disease as of April 10. No patients developed critical disease,
requiring mechanical ventilation, or died of COVID-19.
All patients had a caesarean section in their third trimester. Four of
them had preterm labor between 33 weeks and 37 weeks. Three neonates
(21.4%) had a low birthweight (<2500 g). All the fourteen
neonates had a 1-min Apgar score of 9 and a 5-min Apgar score of 10
except one. Neonate 12 had a 1-min and 5-min Apgar score of 7 and 9,
respectively.
Nasopharyngeal swab specimens were collected successfully in 6 cases at
birth (neonate 1, 3, 4, 7, 11 and 12) for SARS-CoV-2 test by RT-PCR, and
all the results were negative. Additional SARS-CoV-2 test was performed
on cord blood of neonate 7 and the result was negative. However, the
anal swab which performed just after delivery from neonate 11 was
positive for SARS-CoV-2. Additionally, IgG and IgM antibody against
SARS-CoV-2 were analyzed from the peripheral blood of neonate 11. Both
were increased with the IgG titer of 140.32 (reference, 0-10 AU/ml) and
IgM titer of 45.83 (reference, 0-10 AU/ml), respectively (Table 4).