Acknowledgments
The authors would like to thank all of the clinicians and families who made this study possible by providing samples. The authors would also like to thank Mr. Akitaka Sugishita, Ms. Yoshie Miura, Ms. Hiroko Ono, and Ms. Chie Amahori for their valuable assistance. The authors acknowledge the help of the Division for Medical Research Engineering, Nagoya University Graduate School of Medicine, regarding technical support with next-generation sequencing. The authors also acknowledge the help of the Human Genome Center, University of Tokyo, for providing super-computing resources (http://sc.hgc.jp/shirokane.html).