Potential implication of PARP inhibitors in Covid-19
Several evidences have supported the involvement of PARP1 in oxidative
stress mediated response, inflammation and various diseases. PARP-1
mediated inflammatory response caused by bacteria and other pathogenic
agents like parasite and fungi has been elucidated. PARP1 is also known
to regulate cytokine production and the string analysis also depict
direct PARP1 interaction with some cytokines and indirect with few other
cytokines known to be involved in Covid-19 (Fig 1). Although there are
reports of PARP1 regulation of virus-host interaction and virus
infection, but detailed mechanistic studies are required as PARP1
involvement in virus mediated inflammation is not elucidated fully.
PARP1 mediated inflammation during fibrosis, ischaemia and stroke and
its relationship with viruses, inspired us to think about probability of
role of PARP1 in SARS-CoV-2 mediated inflammation. Further work is
required to identify the link between SARS-CoV-2 virus infection and
PARP1 mediated inflammation.