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We discriminated liver injury associated with COVID-19 by temporal patterns, e.g., admission to the hospital, in-hospital, and cumulative incidence that took both time points into account. We also linked the time of illness onset that refers to the onset of symptoms. Hepatoprotective drugs used in the study included magnesium isoglycyrrhizinate, diammonium glycyrrhizinate, and polyene phosphatidylcholine.