REFERENCES
1. Silverberg JI, Hanifin JM. Adult eczema prevalence and associations
with asthma and other health and demographic factors: A US
population–based study. Journal of Allergy and Clinical
Immunology. 2013;132(5):1132-1138.
2. Nutten S. Atopic Dermatitis: Global Epidemiology and Risk Factors.Annals of Nutrition and Metabolism. 2015;66(suppl 1)(Suppl.
1):8-16.
3. Suárez-Fariñas M, Ungar B, Correa da Rosa J, et al. RNA sequencing
atopic dermatitis transcriptome profiling provides insights into novel
disease mechanisms with potential therapeutic implications.Journal of Allergy and Clinical Immunology.2015;135(5):1218-1227.
4. Sanyal RD, Pavel AB, Glickman J, et al. Atopic dermatitis in African
American patients is T(H)2/T(H)22-skewed with T(H)1/T(H)17 attenuation.Annals of allergy, asthma & immunology : official publication of
the American College of Allergy, Asthma, & Immunology.2019;122(1):99-110.e116.
5. Nomura I, Gao B, Boguniewicz M, Darst MA, Travers JB, Leung DY.
Distinct patterns of gene expression in the skin lesions of atopic
dermatitis and psoriasis: a gene microarray analysis. J Allergy
Clin Immunol. 2003;112(6):1195-1202.
6. Broccardo CJ, Mahaffey S, Schwarz J, et al. Comparative proteomic
profiling of patients with atopic dermatitis based on history of eczema
herpeticum infection and Staphylococcus aureus colonization. J
Allergy Clin Immunol. 2011;127(1):186-193, 193.e181-111.
7. Brunner PM, Israel A, Zhang N, et al. Early-onset pediatric atopic
dermatitis is characterized by TH2/TH17/TH22-centered inflammation and
lipid alterations. J Allergy Clin Immunol. 2018;141(6):2094-2106.
8. He H, Del Duca E, Diaz A, et al. Mild atopic dermatitis lacks
systemic inflammation and shows reduced nonlesional skin abnormalities.J Allergy Clin Immunol. 2021;147(4):1369-1380.
9. He H, Suryawanshi H, Morozov P, et al. Single-cell transcriptome
analysis of human skin identifies novel fibroblast subpopulation and
enrichment of immune subsets in atopic dermatitis. The Journal of
allergy and clinical immunology. 2020;145(6):1615-1628.
10. Lang CCV, Renert-Yuval Y, Del Duca E, et al. Immune and barrier
characterization of atopic dermatitis skin phenotype in Tanzanian
patients. Ann Allergy Asthma Immunol. 2021;127(3):334-341.
11. Guttman-Yassky E, Bissonnette R, Ungar B, et al. Dupilumab
progressively improves systemic and cutaneous abnormalities in patients
with atopic dermatitis. Journal of Allergy and Clinical
Immunology. 2019;143(1):155-172.
12. Zhou L, Leonard A, Pavel AB, et al. Age-specific changes in the
molecular phenotype of patients with moderate-to-severe atopic
dermatitis. J Allergy Clin Immunol. 2019;144(1):144-156.
13. Greenwood JD, Merry SP, Boswell CL. Skin Biopsy Techniques.Prim Care. 2022;49(1):1-22.
14. Llamas-Velasco M, Paredes BE. Basic concepts in skin biopsy. Part I.Actas Dermosifiliogr. 2012;103(1):12-20.
15. Fahlén A, Engstrand L, Baker BS, Powles A, Fry L. Comparison of
bacterial microbiota in skin biopsies from normal and psoriatic skin.Arch Dermatol Res. 2012;304(1):15-22.
16. Kim BE, Goleva E, Kim PS, et al. Side-by-Side Comparison of Skin
Biopsies and Skin Tape Stripping Highlights Abnormal Stratum Corneum in
Atopic Dermatitis. J Invest Dermatol.2019;139(11):2387-2389.e2381.
17. He H, Bissonnette R, Wu J, et al. Tape strips detect distinct immune
and barrier profiles in atopic dermatitis and psoriasis. J Allergy
Clin Immunol. 2021;147(1):199-212.
18. Sølberg J, Jacobsen SB, Andersen JD, et al. The stratum corneum
transcriptome in atopic dermatitis can be assessed by tape stripping.J Dermatol Sci. 2021;101(1):14-21.
19. Hulshof L, Hack DP, Hasnoe QCJ, et al. A minimally invasive tool to
study immune response and skin barrier in children with atopic
dermatitis. Br J Dermatol. 2019;180(3):621-630.
20. McAleer MA, Jakasa I, Hurault G, et al. Systemic and stratum corneum
biomarkers of severity in infant atopic dermatitis include markers of
innate and T helper cell-related immunity and angiogenesis. Brit J
Dermatol. 2019;180(3):586-596.
21. Koppes SA, Brans R, Ljubojevic Hadzavdic S, Frings-Dresen MHW,
Rustemeyer T, Kezic S. Stratum Corneum Tape Stripping: Monitoring of
Inflammatory Mediators in Atopic Dermatitis Patients Using Topical
Therapy. International Archives of Allergy and Immunology.2016;170(3):187-193.
22. Clausen ML, Slotved HC, Krogfelt KA, Agner T. Measurements of AMPs
in stratum corneum of atopic dermatitis and healthy skin-tape stripping
technique. Sci Rep. 2018;8(1):1666.
23. Yamaguchi J, Aihara M, Kobayashi Y, Kambara T, Ikezawa Z.
Quantitative analysis of nerve growth factor (NGF) in the atopic
dermatitis and psoriasis horny layer and effect of treatment on NGF in
atopic dermatitis. Journal of Dermatological Science.2009;53(1):48-54.
24. Winget JM, Finlay D, Mills KJ, et al. Quantitative Proteomic
Analysis of Stratum Corneum Dysfunction in Adult Chronic
Atopic Dermatitis. J Invest Dermatol. 2016;136(8):1732-1735.
25. Janssens M, van Smeden J, Gooris GS, et al. Increase in short-chain
ceramides correlates with an altered lipid organization and decreased
barrier function in atopic eczema patients[S]. Journal of
Lipid Research. 2012;53(12):2755-2766.
26. Angelova-Fischer I, Mannheimer A-C, Hinder A, et al. Distinct
barrier integrity phenotypes in filaggrin-related atopic eczema
following sequential tape stripping and lipid profiling.Experimental Dermatology. 2011;20(4):351-356.
27. Broccardo CJ, Mahaffey SB, Strand M, Reisdorph NA, Leung DY. Peeling
off the layers: skin taping and a novel proteomics approach to study
atopic dermatitis. J Allergy Clin Immunol.2009;124(5):1113-1115.e1111-1111.
28. Amarbayasgalan T, Takahashi H, Dekio I, Morita E. Interleukin-8
content in the stratum corneum as an indicator of the severity of
inflammation in the lesions of atopic dermatitis. Int Arch Allergy
Immunol. 2013;160(1):63-74.
29. Mikhaylov D, Del Duca E, Olesen CM, et al. Transcriptomic Profiling
of Tape-Strips From Moderate to Severe Atopic Dermatitis Patients
Treated With Dupilumab. Dermatitis. 2021;32(1s):S71-s80.
30. Guttman-Yassky E, Diaz A, Pavel AB, et al. Use of Tape Strips to
Detect Immune and Barrier Abnormalities in the Skin of Children With
Early-Onset Atopic Dermatitis. JAMA Dermatol.2019;155(12):1358-1370.
31. Olesen CM, Holm JG, Norreslet LB, Serup JV, Thomsen SF, Agner T.
Treatment of atopic dermatitis with dupilumab: experience from a
tertiary referral centre. J Eur Acad Dermatol Venereol.2019;33(8):1562-1568.
32. Lyubchenko T, Collins HK, Goleva E, Leung DYM. Skin tape sampling
technique identifies proinflammatory cytokines in atopic dermatitis
skin. Ann Allergy Asthma Immunol. 2021;126(1):46-53.e42.
33. Clausen ML, Kezic S, Olesen CM, Agner T. Cytokine concentration
across the stratum corneum in atopic dermatitis and healthy controls.Sci Rep. 2020;10(1):21895.
34. Olesen CM, Pavel AB, Wu J, et al. Tape-strips provide a minimally
invasive approach to track therapeutic response to topical
corticosteroids in atopic dermatitis patients. J Allergy Clin
Immunol Pract. 2021;9(1):576-579.e573.
35. Simonsen S, Brøgger P, Kezic S, Thyssen JP, Skov L. Comparison of
Cytokines in Skin Biopsies and Tape Strips from Adults with Atopic
Dermatitis. Dermatology (Basel, Switzerland).2021;237(6):940-945.
36. Andersson AM, Sølberg J, Koch A, et al. Assessment of biomarkers in
pediatric atopic dermatitis by tape strips and skin biopsies.Allergy. 2021.
37. Dyjack N, Goleva E, Rios C, et al. Minimally invasive skin tape
strip RNA sequencing identifies novel characteristics of the type 2-high
atopic dermatitis disease endotype. J Allergy Clin Immunol.2018;141(4):1298-1309.
38. Renert-Yuval Y, Del Duca E, Pavel AB, et al. The molecular features
of normal and atopic dermatitis skin in infants, children, adolescents,
and adults. J Allergy Clin Immunol. 2021;148(1):148-163.
39. Wu J, Del Duca E, Espino M, et al. RNA Sequencing Keloid
Transcriptome Associates Keloids With Th2, Th1, Th17/Th22, and
JAK3-Skewing. Front Immunol. 2020;11:597741.
40. Dobin A, Davis CA, Schlesinger F, et al. STAR: ultrafast universal
RNA-seq aligner. Bioinformatics. 2013;29(1):15-21.
41. Law CW, Chen Y, Shi W, Smyth GK. voom: Precision weights unlock
linear model analysis tools for RNA-seq read counts. Genome Biol.2014;15(2):R29.
42. Ewald DA, Malajian D, Krueger JG, et al. Meta-analysis derived
atopic dermatitis (MADAD) transcriptome defines a robust AD signature
highlighting the involvement of atherosclerosis and lipid metabolism
pathways. BMC Med Genomics. 2015;8:60.
43. Hamilton JD, Suárez-Fariñas M, Dhingra N, et al. Dupilumab improves
the molecular signature in skin of patients with moderate-to-severe
atopic dermatitis. J Allergy Clin Immunol. 2014;134(6):1293-1300.
44. He H, Olesen CM, Pavel AB, et al. Tape-Strip Proteomic Profiling of
Atopic Dermatitis on Dupilumab Identifies Minimally Invasive Biomarkers.Front Immunol. 2020;11:1768.
45. Dhingra N, Shemer A, Correa da Rosa J, et al. Molecular profiling of
contact dermatitis skin identifies allergen-dependent differences in
immune response. The Journal of allergy and clinical immunology.2014;134(2):362-372.
46. Guttman-Yassky E, Ungar B, Noda S, et al. Extensive alopecia areata
is reversed by IL-12/IL-23p40 cytokine antagonism. The Journal of
allergy and clinical immunology. 2016;137(1):301-304.
47. Guttman-Yassky E, Zhou L, Krueger JG. The skin as an immune organ:
Tolerance versus effector responses and applications to food allergy and
hypersensitivity reactions. J Allergy Clin Immunol.2019;144(2):362-374.
48. Guttman-Yassky E, Lowes MA, Fuentes-Duculan J, et al. Major
differences in inflammatory dendritic cells and their products
distinguish atopic dermatitis from psoriasis. J Allergy Clin
Immunol. 2007;119(5):1210-1217.
49. Worm M, Fiedler EM, Dölle S, et al. Exogenous histamine aggravates
eczema in a subgroup of patients with atopic dermatitis. Acta Derm
Venereol. 2009;89(1):52-56.
50. Gutowska-Owsiak D, Greenwald L, Watson C, Selvakumar TA, Wang X, Ogg
GS. The histamine-synthesizing enzyme histidine decarboxylase is
upregulated by keratinocytes in atopic skin. Brit J Dermatol.2014;171(4):771-778.
51. Han SK, Mancino V, Simon MI. Phospholipase Cbeta 3 mediates the
scratching response activated by the histamine H1 receptor on C-fiber
nociceptive neurons. Neuron. 2006;52(4):691-703.
52. Miras-Portugal MT, Menéndez-Méndez A, Gómez-Villafuertes R, et al.
Physiopathological Role of the Vesicular Nucleotide Transporter (VNUT)
in the Central Nervous System: Relevance of the Vesicular Nucleotide
Release as a Potential Therapeutic Target. Frontiers in Cellular
Neuroscience. 2019;13.
53. Gao Z-R, Chen W-Z, Liu M-Z, et al. Tac1-Expressing Neurons in the
Periaqueductal Gray Facilitate the Itch-Scratching Cycle via Descending
Regulation. Neuron. 2019;101(1):45-59.e49.
54. Kahremany S, Hofmann L, Gruzman A, Cohen G. Advances in
Understanding the Initial Steps of Pruritoceptive Itch: How the Itch
Hits the Switch. International journal of molecular sciences.2020;21(14):4883.
55. Moore C, Gupta R, Jordt S-E, Chen Y, Liedtke WB. Regulation of Pain
and Itch by TRP Channels. Neurosci Bull. 2018;34(1):120-142.
56. Datsi A, Steinhoff M, Ahmad F, Alam M, Buddenkotte J.
Interleukin-31: The ”itchy” cytokine in inflammation and therapy.Allergy. 2021;76(10):2982-2997.
57. Akiyama T, Carstens E. Neural processing of itch.Neuroscience. 2013;250:697-714.
58. Cevikbas F, Wang X, Akiyama T, et al. A sensory neuron-expressed
IL-31 receptor mediates T helper cell-dependent itch: Involvement of
TRPV1 and TRPA1. J Allergy Clin Immunol. 2014;133(2):448-460.
59. Feld M, Garcia R, Buddenkotte J, et al. The pruritus- and
TH2-associated cytokine IL-31 promotes growth of sensory nerves. J
Allergy Clin Immunol. 2016;138(2):500-508 e524.
60. Furue M, Yamamura K, Kido-Nakahara M, Nakahara T, Fukui Y. Emerging
role of interleukin-31 and interleukin-31 receptor in pruritus in atopic
dermatitis. Allergy. 2018;73(1):29-36.
61. Zhang Q, Putheti P, Zhou Q, Liu Q, Gao W. Structures and biological
functions of IL-31 and IL-31 receptors. Cytokine Growth Factor
Rev. 2008;19(5-6):347-356.
62. Larkin C, Chen W, Szabó IL, et al. Novel insights into the
TRPV3-mediated itch in atopic dermatitis. J Allergy Clin Immunol.2021;147(3):1110-1114.e1115.
63. Chen W, Li Y, Steinhoff M, et al. The PLAUR signaling promotes
chronic pruritus. FASEB journal : official publication of the
Federation of American Societies for Experimental Biology.2022;36(6):e22368.
64. Krementsov DN, Wall EH, Martin RA, et al. Histamine H3 Receptor
Integrates Peripheral Inflammatory Signals in the Neurogenic Control of
Immune Responses and Autoimmune Disease Susceptibility. PLOS ONE.2013;8(7):e62743.
65. Nauroy P, Nyström A. Kallikreins: Essential epidermal messengers for
regulation of the skin microenvironment during homeostasis, repair and
disease. Matrix Biol Plus. 2020;6-7:100019.
66. Suárez-Fariñas M, Tintle SJ, Shemer A, et al. Nonlesional atopic
dermatitis skin is characterized by broad terminal differentiation
defects and variable immune abnormalities. J Allergy Clin
Immunol. 2011;127(4):954-964.e951-954.
67. Yokouchi M, Kubo A. Maintenance of tight junction barrier integrity
in cell turnover and skin diseases. Experimental Dermatology.2018;27(8):876-883.
68. Dhingra N, Guttman-Yassky E. A Possible Role for IL-17A in
Establishing Th2 Inflammation in Murine Models of Atopic Dermatitis.Journal of Investigative Dermatology. 2014;134(8):2071-2074.
69. He H, Olesen, C.M., Pavel, A.B., Clausen, M., Wu, J., Estrada, Y.,
Zhang, N., Agner, T., and Guttman-Yassky, E. Tape-strip proteomic
profiling of atopic dermatitis on dupilumab identifies minimally
invasive biomarkers. Frontiers in Immunology. 2020.
70. Pavel AB, Renert-Yuval Y, Wu J, et al. Tape strips from early-onset
pediatric atopic dermatitis highlight disease abnormalities in
nonlesional skin. Allergy. 2021;76(1):314-325.
71. Leung DYM, Calatroni A, Zaramela LS, et al. The nonlesional skin
surface distinguishes atopic dermatitis with food allergy as a unique
endotype. Science translational medicine. 2019;11(480).
72. Ścibior K, Romańska-Gocka K, Czajkowski R, Placek W, Zegarska B.
Expression of CD1a, CD207, CD11b, CD11c, CD103, and HLA-DR receptors on
the surface of dendritic cells in the skin of patients with atopic
dermatitis. Postepy dermatologii i alergologii.2019;36(5):544-550.
73. Mias C, Le Digabel J, Filiol J, et al. Visualization of dendritic
cells’ responses in atopic dermatitis: Preventing effect of emollient.Experimental dermatology. 2018;27(4):374-377.
74. Wollenberg A, Kraft S, Hanau D, Bieber T. Immunomorphological and
ultrastructural characterization of Langerhans cells and a novel,
inflammatory dendritic epidermal cell (IDEC) population in lesional skin
of atopic eczema. The Journal of investigative dermatology.1996;106(3):446-453.
75. Yoshida K, Kubo A, Fujita H, et al. Distinct behavior of human
Langerhans cells and inflammatory dendritic epidermal cells at tight
junctions in patients with atopic dermatitis. The Journal of
allergy and clinical immunology. 2014;134(4):856-864.
76. Kolls JK, McCray PB, Jr., Chan YR. Cytokine-mediated regulation of
antimicrobial proteins. Nature reviews Immunology.2008;8(11):829-835.
77. Fujita H. The role of IL-22 and Th22 cells in human skin diseases.Journal of dermatological science. 2013;72(1):3-8.
78. Esaki H, Ewald DA, Ungar B, et al. Identification of novel immune
and barrier genes in atopic dermatitis by means of laser capture
microdissection. The Journal of allergy and clinical immunology.2015;135(1):153-163.
79. Günther C, Wozel G, Meurer M, Pfeiffer C. Up-regulation of CCL11 and
CCL26 is associated with activated eosinophils in bullous pemphigoid.Clinical and experimental immunology. 2011;166(2):145-153.
80. Beck LA, Thaci D, Hamilton JD, et al. Dupilumab treatment in adults
with moderate-to-severe atopic dermatitis. The New England journal
of medicine. 2014;371(2):130-139.
81. Simpson EL, Bieber T, Guttman-Yassky E, et al. Two Phase 3 Trials of
Dupilumab versus Placebo in Atopic Dermatitis. The New England
journal of medicine. 2016;375(24):2335-2348.
82. Wollenberg A, Howell MD, Guttman-Yassky E, et al. Treatment of
atopic dermatitis with tralokinumab, an anti-IL-13 mAb. The
Journal of allergy and clinical immunology. 2019;143(1):135-141.
83. Guttman-Yassky E, Blauvelt A, Eichenfield LF, et al. Efficacy and
Safety of Lebrikizumab, a High-Affinity Interleukin 13 Inhibitor, in
Adults With Moderate to Severe Atopic Dermatitis: A Phase 2b Randomized
Clinical Trial. JAMA dermatology. 2020;156(4):411-420.
84. Silverberg JI, Pinter A, Alavi A, et al. Nemolizumab is associated
with a rapid improvement in atopic dermatitis signs and symptoms:
subpopulation (EASI ≥ 16) analysis of randomized phase 2B study.Journal of the European Academy of Dermatology and Venereology :
JEADV. 2021;35(7):1562-1568.
85. Guttman-Yassky E, Pavel AB, Zhou L, et al. GBR 830, an anti-OX40,
improves skin gene signatures and clinical scores in patients with
atopic dermatitis. The Journal of allergy and clinical
immunology. 2019;144(2):482-493 e487.
86. Brunner PM, Pavel AB, Khattri S, et al. Baseline IL-22 expression in
patients with atopic dermatitis stratifies tissue responses to
fezakinumab. The Journal of allergy and clinical immunology.2019;143(1):142-154.
87. Guttman-Yassky E, Brunner PM, Neumann AU, et al. Efficacy and safety
of fezakinumab (an IL-22 monoclonal antibody) in adults with
moderate-to-severe atopic dermatitis inadequately controlled by
conventional treatments: A randomized, double-blind, phase 2a trial.Journal of the American Academy of Dermatology.2018;78(5):872-881 e876.
88. Ruzicka T, Hanifin JM, Furue M, et al. Anti-Interleukin-31 Receptor
A Antibody for Atopic Dermatitis. The New England journal of
medicine. 2017;376(9):826-835.
89. Kabashima K. New concept of the pathogenesis of atopic dermatitis:
interplay among the barrier, allergy, and pruritus as a trinity.Journal of dermatological science. 2013;70(1):3-11.
90. Eichenfield LF, Tom WL, Chamlin SL, et al. Guidelines of care for
the management of atopic dermatitis: section 1. Diagnosis and assessment
of atopic dermatitis. Journal of the American Academy of
Dermatology. 2014;70(2):338-351.
91. Wei W, Anderson P, Gadkari A, et al. Extent and consequences of
inadequate disease control among adults with a history of moderate to
severe atopic dermatitis. The Journal of dermatology.2018;45(2):150-157.
92. Miake S, Tsuji G, Takemura M, et al. IL-4 Augments IL-31/IL-31
Receptor Alpha Interaction Leading to Enhanced Ccl 17 and Ccl 22
Production in Dendritic Cells: Implications for Atopic Dermatitis.International journal of molecular sciences. 2019;20(16).
93. Andoh T, Harada A, Kuraishi Y. Involvement of Leukotriene B4
Released from Keratinocytes in Itch-associated Response to Intradermal
Interleukin-31 in Mice. Acta dermato-venereologica.2017;97(8):922-927.
94. Miron Y, Miller PE, Hughes C, Indersmitten T, Lerner EA, Cevikbas F.
Mechanistic insights into the antipruritic effects of lebrikizumab, an
anti-IL-13 mAb. The Journal of allergy and clinical immunology.2022;150(3):690-700.
95. Oh MH, Oh SY, Lu J, et al. TRPA1-dependent pruritus in IL-13-induced
chronic atopic dermatitis. Journal of immunology (Baltimore, Md :
1950). 2013;191(11):5371-5382.
96. Szöllősi AG, Vasas N, Angyal Á, et al. Activation of TRPV3 Regulates
Inflammatory Actions of Human Epidermal Keratinocytes. The Journal
of investigative dermatology. 2018;138(2):365-374.
97. Um JY, Kang SY, Kim HJ, Chung BY, Park CW, Kim HO. Transient
receptor potential vanilloid-3 (TRPV3) channel induces dermal fibrosis
via the TRPV3/TSLP/Smad2/3 pathways in dermal fibroblasts. Journal
of dermatological science. 2020;97(2):117-124.
98. Wang M, Sun Y, Li L, Wu P, Dkw O, Shi H. Calcium Channels:
Noteworthy Regulators and Therapeutic Targets in Dermatological
Diseases. Frontiers in pharmacology. 2021;12:702264.
99. Park CW, Kim HJ, Choi YW, et al. TRPV3 Channel in Keratinocytes in
Scars with Post-Burn Pruritus. International journal of molecular
sciences. 2017;18(11).
100. Lehen’kyi V, Beck B, Polakowska R, et al. TRPV6 is a Ca2+ entry
channel essential for Ca2+-induced differentiation of human
keratinocytes. The Journal of biological chemistry.2007;282(31):22582-22591.
101. Kim N, Bae KB, Kim MO, et al. Overexpression of cathepsin S induces
chronic atopic dermatitis in mice. The Journal of investigative
dermatology. 2012;132(4):1169-1176.
102. Reddy VB, Shimada SG, Sikand P, Lamotte RH, Lerner EA. Cathepsin S
elicits itch and signals via protease-activated receptors. The
Journal of investigative dermatology. 2010;130(5):1468-1470.
103. Billi AC, Ludwig JE, Fritz Y, et al. KLK6 expression in skin
induces PAR1-mediated psoriasiform dermatitis and inflammatory joint
disease. The Journal of clinical investigation.2020;130(6):3151-3157.
104. Imamachi N, Park GH, Lee H, et al. TRPV1-expressing primary
afferents generate behavioral responses to pruritogens via multiple
mechanisms. Proceedings of the National Academy of Sciences of the
United States of America. 2009;106(27):11330-11335.
105. Neisius U, Olsson R, Rukwied R, Lischetzki G, Schmelz M.
Prostaglandin E2 induces vasodilation and pruritus, but no protein
extravasation in atopic dermatitis and controls. Journal of the
American Academy of Dermatology. 2002;47(1):28-32.
106. Peier AM, Reeve AJ, Andersson DA, et al. A heat-sensitive TRP
channel expressed in keratinocytes. Science (New York, NY).2002;296(5575):2046-2049.
107. Khalil M, Alliger K, Weidinger C, et al. Functional Role of
Transient Receptor Potential Channels in Immune Cells and Epithelia.Front Immunol. 2018;9:174.
108. Larkin C, Chen W, Szabó IL, et al. Novel insights into the
TRPV3-mediated itch in atopic dermatitis. The Journal of allergy
and clinical immunology. 2021;147(3):1110-1114 e1115.
109. Wu Z, Hansmann B, Meyer-Hoffert U, Gläser R, Schröder JM. Molecular
identification and expression analysis of filaggrin-2, a member of the
S100 fused-type protein family. PloS one. 2009;4(4):e5227.
110. Kvedar JC, Manabe M, Phillips SB, Ross BS, Baden HP.
Characterization of sciellin, a precursor to the cornified envelope of
human keratinocytes. Differentiation; research in biological
diversity. 1992;49(3):195-204.
111. Abbas Zadeh S, Mlitz V, Lachner J, et al. Phylogenetic profiling
and gene expression studies implicate a primary role of PSORS1C2 in
terminal differentiation of keratinocytes. Experimental
dermatology. 2017;26(4):352-358.
112. Zouboulis CC, Nogueira da Costa A, Makrantonaki E, et al.
Alterations in innate immunity and epithelial cell differentiation are
the molecular pillars of hidradenitis suppurativa. Journal of the
European Academy of Dermatology and Venereology : JEADV.2020;34(4):846-861.
113. De Benedetto A, Rafaels NM, McGirt LY, et al. Tight junction
defects in patients with atopic dermatitis. The Journal of allergy
and clinical immunology. 2011;127(3):773-786 e771-777.
114. Au A, Shao Q, White KK, et al. Comparative Analysis of Cx31 and
Cx43 in Differentiation-Competent Rodent Keratinocytes.Biomolecules. 2020;10(10).
115. Berdyshev E, Goleva E, Bronova I, et al. Lipid abnormalities in
atopic skin are driven by type 2 cytokines. JCI insight.2018;3(4).
116. Esaki H, Brunner PM, Renert-Yuval Y, et al. Early-onset pediatric
atopic dermatitis is TH2 but also TH17 polarized in skin. The
Journal of allergy and clinical immunology. 2016;138(6):1639-1651.
117. Guttman-Yassky E, Suarez-Farinas M, Chiricozzi A, et al. Broad
defects in epidermal cornification in atopic dermatitis identified
through genomic analysis. The Journal of allergy and clinical
immunology. 2009;124(6):1235-1244 e1258.
118. Noda S, Suarez-Farinas M, Ungar B, et al. The Asian atopic
dermatitis phenotype combines features of atopic dermatitis and
psoriasis with increased TH17 polarization. The Journal of allergy
and clinical immunology. 2015;136(5):1254-1264.
119. Schäfer L, Kragballe K. Abnormalities in epidermal lipid metabolism
in patients with atopic dermatitis. The Journal of investigative
dermatology. 1991;96(1):10-15.
120. Vietri Rudan M, Watt FM. Mammalian Epidermis: A Compendium of Lipid
Functionality. Frontiers in physiology. 2021;12:804824.
121. Picardo M, Ottaviani M, Camera E, Mastrofrancesco A. Sebaceous
gland lipids. Dermato-endocrinology. 2009;1(2):68-71.
122. Cheng JB, Russell DW. Mammalian wax biosynthesis. I. Identification
of two fatty acyl-Coenzyme A reductases with different substrate
specificities and tissue distributions. The Journal of biological
chemistry. 2004;279(36):37789-37797.
123. Ge L, Gordon JS, Hsuan C, Stenn K, Prouty SM. Identification of the
delta-6 desaturase of human sebaceous glands: expression and enzyme
activity. The Journal of investigative dermatology.2003;120(5):707-714.
124. Renert-Yuval Y, Pavel AB, Bose S, et al. Tape strips capture atopic
dermatitis-related changes in nonlesional skin throughout maturation.Allergy. 2022.