References
Bai, K., W. Liu, C. Liu, Y. Fu, J. Hu, Y. Qin, Q. Zhang, H. Chen, F. Xu and C. Li (2020). ”Clinical Analysis of 25 COVID-19 Infections in Children.” Pediatr Infect Dis J39 (7): e100-e103.
Bi, Q., Y. Wu, S. Mei, C. Ye, X. Zou, Z. Zhang, X. Liu, L. Wei, S. A. Truelove and T. Zhang (2020). ”Epidemiology and transmission of COVID-19 in 391 cases and 1286 of their close contacts in Shenzhen, China: a retrospective cohort study.” The Lancet Infectious Diseases.
Bitnun, A., U. Allen, H. Heurter, S. M. King, M. A. Opavsky, E. L. Ford-Jones, A. Matlow, I. Kitai, R. Tellier and S. Richardson (2003). ”Children hospitalized with severe acute respiratory syndrome-related illness in Toronto.” Pediatrics112 (4): e261-e261.
Dong, Y., X. Mo, Y. Hu, X. Qi, F. Jiang, Z. Jiang and S. Tong (2020). ”Epidemiological characteristics of 2143 pediatric patients with 2019 coronavirus disease in China.” Pediatrics.
Guan, W.-j., Z.-y. Ni, Y. Hu, W.-h. Liang, C.-q. Ou, J.-x. He, L. Liu, H. Shan, C.-l. Lei and D. S. Hui (2020). ”Clinical characteristics of coronavirus disease 2019 in China.” New England Journal of Medicine.
Guo, Y.-R., Q.-D. Cao, Z.-S. Hong, Y.-Y. Tan, S.-D. Chen, H.-J. Jin, K.-S. Tan, D.-Y. Wang and Y. Yan (2020). ”The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak–an update on the status.” Military Medical Research 7 (1): 1-10.
Henry, B. M. (2020). ”COVID-19, ECMO, and lymphopenia: a word of caution.” The Lancet Respiratory Medicine8 (4): e24.
Henry, B. M., M. H. S. de Oliveira, S. Benoit, M. Plebani and G. Lippi (2020). ”Hematologic, biochemical and immune biomarker abnormalities associated with severe illness and mortality in coronavirus disease 2019 (COVID-19): a meta-analysis.” Clin Chem Lab Med.
Hon, K., C. Leung, W. Cheng, P. Chan, W. Chu, Y. Kwan, A. Li, N. Fong, P. Ng and M. Chiu (2003). ”Clinical presentations and outcome of severe acute respiratory syndrome in children.” The Lancet 361 (9370): 1701-1703.
Huppert, F. A., E. M. Pinto, K. Morgan, M. CFAS and C. Brayne (2003). ”Survival in a population sample is predicted by proportions of lymphocyte subsets.” Mechanisms of ageing and development 124 (4): 449-451.
Liu, J., S. Li, B. Liang, X. Wang, H. Wang, W. Li, Q. Tong, J. Yi, L. Zhao, L. Xiong, C. Guo, J. Tian, J. Luo, J. Yao, R. Pang, H. Shen, C. Peng, T. Liu, Q. Zhang, J. Wu, L. Xu, S. Lu, B. Wang, Z. Weng, C. Han, H. Zhu, R. Zhou, H. Zhou, X. Chen, P. Ye, B. Zhu, L. Wang, W. Zhou, S. He, Y. He, S. Jie, P. Wei, J. Zhang, Y. Lu, W. Wang, L. Zhang, L. Li, F. Zhou, J. Wang, U. Dittmer, M. Lu, Y. Hu, D. Yang and X. Zheng (2020). ”Longitudinal characteristics of lymphocyte responses and cytokine profiles in the peripheral blood of SARS-CoV-2 infected patients.” EBioMedicine 55 : 102763.
Lotfi, M. and N. Rezaei (2020). ”SARS-CoV-2: A comprehensive review from pathogenicity of the virus to clinical consequences.” J Med Virol.
Maeda, I. S., N Iida, M Matsumoto, H Hashimoto, S Hirose, N (1999). ”Relationship between CD4+/CD8+ T cell ratio and T cell activation in systemic lupus erythematosus.” Scandinavian journal of rheumatology 28 (3): 166-170.
Margolick, J. B., A. Munoz, A. D. Donnenberg, L. P. Park, N. Galai, J. V. Giorgi, M. R. O’Gorman and J. Ferbas (1995). ”Failure of T-cell homeostasis preceding AIDS in HIV-1 infection. The Multicenter AIDS Cohort Study.” Nat Med 1 (7): 674-680.
McBride, J. A. and R. Striker (2017). ”Imbalance in the game of T cells: what can the CD4/CD8 T-cell ratio tell us about HIV and health?” PLoS pathogens 13 (11).
Ng, C. T., L. M. Snell, D. G. Brooks and M. B. Oldstone (2013). ”Networking at the level of host immunity: immune cell interactions during persistent viral infections.” Cell Host Microbe 13 (6): 652-664.
Ni, M., F. B. Tian, D. D. Xiang and B. Yu (2020). ”Characteristics of inflammatory factors and lymphocyte subsets in patients with severe COVID-19.” J Med Virol.
Reker-Hadrup, S., J. Strindhall, T. Kollgaard, T. Seremet, B. Johansson, G. Pawelec, P. Strat and A. Wikby (2006). ”Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage predicting mortality and increased number of dysfunctional cytomegalovirus-specific T cells in the elderly.” J Immunol 176 (4): 2645-2653.
Saghazadeh, A. and N. Rezaei (2020). ”Immune-epidemiological parameters of the novel coronavirus–a perspective.” Expert Review of Clinical Immunology: 1-6.
Simpson, S., F. U. Kay, S. Abbara, S. Bhalla, J. H. Chung, M. Chung, T. S. Henry, J. P. Kanne, S. Kligerman and J. P. Ko (2020). ”Radiological Society of North America Expert Consensus Statement on Reporting Chest CT Findings Related to COVID-19. Endorsed by the Society of Thoracic Radiology, the American College of Radiology, and RSNA.” Radiology: Cardiothoracic Imaging 2 (2): e200152.
Sohrabi, C., Z. Alsafi, N. O’Neill, M. Khan, A. Kerwan, A. Al-Jabir, C. Iosifidis and R. Agha (2020). ”World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19).” International Journal of Surgery.
Sun, D., H. Li, X.-X. Lu, H. Xiao, J. Ren, F.-R. Zhang and Z.-S. Liu (2020). ”Clinical features of severe pediatric patients with coronavirus disease 2019 in Wuhan: a single center’s observational study.” World Journal of Pediatrics: 1-9.
Tang, X., C. Wu, X. Li, Y. Song, X. Yao, X. Wu, Y. Duan, H. Zhang, Y. Wang and Z. Qian (2020). ”On the origin and continuing evolution of SARS-CoV-2.” National Science Review.
Wang, D., B. Hu, C. Hu, F. Zhu, X. Liu, J. Zhang, B. Wang, H. Xiang, Z. Cheng and Y. Xiong (2020). Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA [Internet]. 2020 Feb [cited 2020 Mar 23]; 323 (11): 1061-9.
Wang, F., J. Nie, H. Wang, Q. Zhao, Y. Xiong, L. Deng, S. Song, Z. Ma, P. Mo and Y. Zhang (2020). ”Characteristics of Peripheral Lymphocyte Subset Alteration in COVID-19 Pneumonia.” J Infect Dis 221 (11): 1762-1769.
Yang, A. P., H. M. Li, W. Q. Tao, X. J. Yang, M. Wang, W. J. Yang and J. P. Liu (2020). ”Infection with SARS-CoV-2 causes abnormal laboratory results of multiple organs in patients.” Aging (Albany NY) 12 .
Yazdanpanah, F., M. R. Hamblin and N. Rezaei (2020). ”The immune system and COVID-19: Friend or foe?” Life Sci: 117900.
Zhang, W., Y. Zhao, F. Zhang, Q. Wang, T. Li, Z. Liu, J. Wang, Y. Qin, X. Zhang and X. Yan (2020). ”The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The experience of clinical immunologists from China.” Clinical Immunology: 108393.
Table 1. The patients’ laboratory findings and blood lymphocyte subsets of children with COVID-19