Results
A total of 106 cycles met the Bologna criteria (44.8%) in this study
period. Among these cycles, they were divided into group A with
supplementation of DHEA combining Metformin (n = 64) and group B without
supplementation (n = 42). There were no differences between the two
groups regarding age, body mass index, basal follicle stimulation
hormone concentration (FSH), basal estradiol concentration (E2), basal
antral follicle counts (AFC), Anti-Müllerian hormone concentration (AMH)
and Bologna criteria category.
The treatment cycle outcomes between the two groups were compared (Table
1). There were no significant differences in terms of stimulation
duration, gonadotropin dosage, estradiol level on hCG day, and
fertilization rate. Although not statistically significant, there is a
trend of higher number of metaphase II oocytes retrieved (2.1±1.5 vs.
1.0±0.8, p = 0.115) in group A than group B. Furthermore, the
number of oocytes retrieved (3.5±2.5 vs. 1.5±0.8, p = 0.027), the
clinical pregnancy rate (21.7 vs. 11.5, p = 0.008) and the live
birth rates (16.7 vs. 8.7, p = 0.007) were significantly higher
in group A than in group B.