CONCLUSION
Elevated pulmonary artery pressure is associated with dysfunction of the right atrium and right ventricle as shown by decreased RV and RA peak global longitudinal strain. We believe that this chronic dysfunction may be related to an eventual risk for fibrosis. The use of echocardiographic derived strain parameters in clinical practice could be a potential tool for detecting the presence and evaluating the probability of PH as estimated by sPAP. If validated, proposed cut-off values may improve the clinical staging of pulmonary hypertension by including a non-invasive marker of dysfunction or fibrosis.
ACKNOWLEDGMENTS: The authors would like to acknowledge all the staff of the Nuclear Cardiology Department at Instituto Nacional de Cardiologia Ignacio Chavez, particularly to the nurses and technicians. NEAV and ECG are enrolled at the PECEM program of the Faculty of Medicine, and CONACyT supports them.
CONFLICT OF INTERESTS: The authors declare that they have no conflict of interests.
AUTHORS’ CONTRIBUTIONS: Research idea and study design NEZ, NEAV, EAR; data acquisition: RAS, GCC, AAF, DOC; data analysis/interpretation: NEZ, NEAV, ECG; statistical analysis: NEAV, ECG; manuscript drafting: NEZ, NEAV, LR, EAR NCN; supervision or mentorship: NEZ, LR. Each author contributed important intellectual content during manuscript drafting or revision and accepts accountability for the overall work by ensuring that questions pertaining to the accuracy or integrity of any portion of the work are appropriately investigated and resolved. NEZ, NEAV, LR, RAS, GCC, AAF, DOC, EAR
FUNDING: No funding was received.