Primary endpoints
A significant benefit was observed with first-line catheter ablation compared to medical management in survival-free from appropriate ICD therapies, with a 26% relative risk reduction and 14% absolute risk reduction when compared with the medical treatment group (RR 0.70, 95% CI 0.56-0.86) (Figure 2 ). There was no difference in all-cause mortality (RR 0.98, 95% CI 0.52-1.82) and in adverse events between both treatment strategies (RR 1.51, 95% CI 0.89-2.54) (Supplemental Figure 1 ).