Sensitivity analysis
Sensitivity analysis for the secondary endpoints involving the removal of each of the studies sequentially demonstrated that if some of the studies were removed from the analysis, the summary risk estimates for the composite survival-free VT/VF and appropriate ICD therapies was not influenced making the overall results significant (Figure 4 ). The chronologic cumulative analysis for each outcome before inclusion of all studies in the final effect summary did not have a significant impact in the overall final effect (oldest RCT from 2007 and most recent in 2020) (Figure 4 ).