Secondary endpoints
In patients with moderately depressed LVEF (>30-50%),
survival-free from VT/VF in patients who underwent first-line catheter
ablation was 56% vs. 45% in those receiving conservative treatment. A
significant benefit of survival-free from VT/VF was observed with
first-line catheter ablation, with a 24% relative risk reduction and
11% absolute risk reduction when compared with the medical treatment
group (HR: 0.56, 95% CI: 0.38-0.83) (Figure 2 ).
First line VT ablation was associated with a statistically significant
reduction in the composite endpoint of survival-free VT/VF and
appropriate ICD therapies in patients with moderately reduced LVEF (HR:
0.52, 95% CI: 0.36-0.76) (Figure 3) . In patients with severely
depressed LVEF (</=30%), first line VT ablation was not
associated with a reduction in the composite endpoint of survival-free
VT/VF and appropriate ICD therapies (HR: 0.56, 95% CI: 0.24-1.32)(Figure 3) .