FIGURE LEGENDS
Figure 1. Flow chart of study selection
Figure 2. Survival-free from VT/VF and from appropriate ICD
therapies in patients with ICM presenting with VT undergoing first-line
catheter ablation compared to medical management. (A )
Survival-free from appropriate ICD therapies in all patients;
(B ) Survival-free from VT/VF in patients with moderately
depressed LVEF (>30-50%). ICD: implantable-cardioverter
defibrillator; ICM: ischemic cardiomyopathy; VF: ventricular
fibrillation; VT: ventricular tachycardia.
Figure 3. Forest plot reporting the hazard ratio illustrating
the composite endpoint of survival-free VT/VF and appropriate ICD
therapies in patients with ICM presenting with VT undergoing first-line
catheter ablation compared to conservative treatment. (A )
Patients with moderately depressed LVEF (>30-50%);
(B ) Patients with severely depressed LVEF (</=30%).
Diamond indicates overall summary estimates for the analysis: width of
the diamond represents 95% CI; width of the shaded square represents
the size of the population (fixed effects model was used in the
analysis). CI: confidence interval; ICM: ischemic cardiomyopathy; VF:
ventricular fibrillation; VT: ventricular tachycardia.
Figure 4. Forest plots reporting the sensitivity analysis for
the secondary endpoint: (A) leave-one-study-out method for moderately
depressed LVEF; (B) leave-one-study-out method for severely depressed
LVEF; (C) Chronological cumulative analysis for moderately depressed
LVEF; (D) Chronological cumulative analysis for severely depressed LVEF.
Diamond indicates overall summary estimate for the analysis (width of
the diamond represents the 95% CI); width of the shaded square, size of
the population. CI = Confidence interval; ICD: implantable-cardioverter
defibrillator; ICM: ischemic cardiomyopathy; LVEF: left ventricular
ejection fraction; VF: ventricular fibrillation; VT: ventricular
tachycardia.
Figure 5. (A) Methodological quality graph and (B)
Methodological quality summary for the risk of bias from the included
randomized controlled trials using the 6 domains of the Cochrane tool.