3.3 Association between donor CSF3R SNPs and engraftment of
platelets and neutrophils
CSF3R SNPs from healthy donors or autologous transplantation from
patients with hematologic malignancies have now been shown to be related
to peripheral blood stem cell enrichment [9].
Therefore, we wanted to determine whether the distribution of CSF3R SNPs
in this study correlated with CD34 enrichment. The results showed that
no SNPs were associated with CD34 enrichment.
CSF3R is a special receptor for G-CSF signaling and thus plays an
important role in neutrophil development, survival and
function[11]. We therefore explored the
associations of CSF3R SNPs with neutrophils and PLT engraftment. The
results showed that no associations were observed between the genotype
frequencies of these six CSF3R SNPs and the engraftment of platelets or
neutrophils (data not shown).