2.6 Statistical analyses
The Mann-Whitney U test was used to compare continuous variables, and the chi-square test or Fisher exact statistic was used to compare categorical variables. Cumulative incidence curves were used in a competing risk setting, with TRM related as a competing event, to calculate relapse probabilities. The probabilities of LFS and OS were estimated with the Kaplan-Meier method. All variables in Table 1 and Table 2 were included in the univariate analysis. Only variables with a P <.10, including T cells from donors, PLT, rs3917980 and rs2275472 in CSF3R SNPs and disease risk, were included in a Cox proportional hazards model with time-dependent variables. P values were based on 2-sided hypothesis tests. The alpha level was set at .05. All data analyses were performed with the R Foundation for Statistical Computing 3.5.3 using the packages cmprsk, survival, surviminer.