3.3 Association between donor CSF3R SNPs and engraftment of platelets and neutrophils
CSF3R SNPs from healthy donors or autologous transplantation from patients with hematologic malignancies have now been shown to be related to peripheral blood stem cell enrichment [9]. Therefore, we wanted to determine whether the distribution of CSF3R SNPs in this study correlated with CD34 enrichment. The results showed that no SNPs were associated with CD34 enrichment.
CSF3R is a special receptor for G-CSF signaling and thus plays an important role in neutrophil development, survival and function[11]. We therefore explored the associations of CSF3R SNPs with neutrophils and PLT engraftment. The results showed that no associations were observed between the genotype frequencies of these six CSF3R SNPs and the engraftment of platelets or neutrophils (data not shown).