The rs3917980 genotype was associated with better LFS and OS in
patients post allo-HSCT
As rs3917980 and rs2275472 SNPs showed a completely opposite effect on
clinical prognosis after transplantation in univariate analysis and
approximately 33% of the healthy donors carried two SNPs, we speculated
whether the biological effects caused by the above SNPs would be weaker
than those caused by a single SNP. Then, we divided all patients into
the following four groups according to whether their corresponding
donors contained two SNPs: rs3917980G/G or A/G genotype single-positive
group, rs2275472 T/C genotype single-positive group, double-positive
group and double-negative group. Because the number of positive patients
was only 4 out of 273, we created a group with double-negative SNPs.
Cumulative analysis of LFS and OS showed that recipients receiving
grafts from healthy donors with the rs3917980 G/G or A/G genotype had
higher LFS rates than those who received grafts from healthy donors with
the rs22754272 T/C genotype (p=.037) (Fig 4A), while the LFS and OS
rates of the wild-type genotype in the group with double-negative SNPs
were between the values of the above groups, further proving that the
rs3917980 G/G or A/G genotype may be a strong protective factor for a
better LFS; whoever no significant differences were found among the
groups (p=.14) (Fig 4B).