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\begin{document}

\title{Increased Women's Cardiovascular Mortality in their forties after
Hypertensive Disorders of Pregnancy: A national cohort study}



\author[1]{Sophie Welters}%
\author[1]{Pim Teunissen}%
\author[2]{Anita Ravelli}%
\author[3]{Wietske Hermes}%
\author[1]{Christianne de Groot}%
\affil[1]{Amsterdam UMC}%
\affil[2]{Amsterdam UMC - Locatie AMC}%
\affil[3]{Medisch Centrum Haaglanden Westeinde}%


\vspace{-1em}



  
  \date{May 20, 2024}


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\begin{abstract}
Objective: To determine the association between HDP and cardiovascular
mortality. Design: Cohort study Setting: Population based using the
Dutch National Birth Hospital Registry linked with the National Death
Registry. Population: All women who gave birth between 1995 -- 2015
Methods: Cox-regression models with hazard ratios (HR) and survival
curves were executed. Main outcome and measures: The cardiovascular
mortality risk after HDP was analyzed. Cardiovascular mortality-risk was
analyzed in women with a history of HDP in one or more pregnancies
compared to women without a history of HDP. In a subgroup of this cohort
the effect of HDP on cardiovascular mortality was analyzed using only
the nulliparous pregnancy of women. Results: Women were followed for a
mean time of 10.4 years. Of 1,625,246 parous women 21.9\% had a history
of HDP. Gestational hypertension (18.1\%) was associated with an aHR of
2.13 (95\% CI: 1.91 -- 2.38) for CVM. Preeclampsia (3.8\%) was
associated with an aHR of 3.35 (95 \%CI: 2.80 -- 4.00) for CVM.
Cardiovascular mortality risk was highest in women with a history of HDP
combined with a preterm birth (\textless{}37 weeks) and a growth
restricted child (%
\end{abstract}%



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