Figure 1: Symptoms and grades of cytokine release syndrome, also
known as cytokine storm and its impact on drug exposure
Figure 2. Effect of age (A) and Race (B) on plasma
concentration –time profiles of COVID-19 drugs
The black continuous line represents the median prediction using the
PBPK model for 18-40yrs of age; green line for 40 to 65 years and red
line for 65 to 98 years of age. The shaded area represents the 95%
prediction intervals of Caucasian healthy volunteers. In Figure 2B, the
black continuous line represents the median prediction using the PBPK
model for Caucasians subjects. green line is for Japanese subjects and
red line for Chinese patients. All these effect of Race simulations were
run using 40 to 65 years of age with 50% of females.
Doses used: Acalabrutinib 100mg single dose, azithromycin 500mg single
dose, chloroquine 600 mg single dose, dapagliflozin 10mg single dose,
darunavir 800mg single dose, hydroxychloroquine (HCQ) 200mg single dose,
ibrutinib 140 mg single dose; lopinavir 400mg single dose (with 100mg
ritonavir concomitant interaction, rifampicin 600 mg single dose,
baricitinib 2mg single dose, ritonavir 600mg single dose, ruxolitinib
20mg single dose.