Introduction
Infants account for 2-5% and 6-14% of childhood acute lymphoblastic leukemias and acute myeloid leukemias, respectively (1). Patients in this group are characterized by hyperleukocytosis, hepatosplenomegaly, absence of CD 10 expression in the blasts, MLL rearrangement, and central nerve system involvement. The findings of extramedullary invasion may be the first symptom without any abnormality in peripheral blood. These features are associated with poor prognosis and treatment success is low despite intensive chemotherapy (2-4). MLL (11q23) rearrangement is present in 66% of infant acute lymphoblastic leukemia (ALL)s and 35% of acute myeloid leukemia (AML)s . Among infant leukemias with t(4; 11) event-free survival of ALL are lower than that of AMLs (5). Besides, clinical features change according to the opposite chromosome where MLL is translocated. Since it is the most common genetic feature, studies on infant leukemia focus on MLL rearrangements. Rare translocations are also seen in infant leukemias. t (5; 15) which is very rare has been reported in 7 infant ALL cases (4,6). In addition, various anomalies have been reported in infant leukemias. However, the relationship of these anomalies with leukemia is uncertain (7). Here we report a case with t (5; 15) (p15; q11.2) infant leukemia and ectrodactyly.