Outcomes between VTE and AF cohorts
The outcomes between VTE and AF cohort obtained After propensity matching are shown in Supplemental table 4 and Figure 2. The risk of the arterial thromboembolic events was lower in the VTE cohort (subdistribution hazard ratio [SHR], 0.60; 95% confidence interval [CI], 0.57–0.62) (Figure 2A), as were the risks of ischemic stroke (SHR, 0.44; 95% CI, 0.42–0.46) (Figure 2B) and MI (SHR, 0.80; 95% CI, 0.72–0.89). The risk of ECATE (SHR, 1.23; 95% CI, 1.14–1.33) (Figure 2C) and all-cause mortality rate (HR, 1.18; 95% CI, 1.15–1.21) was higher in VTE cohort (Figure 2E), although the latter had lower CV death (HR, 0.96; 95% CI, 0.93–0.995) (Figure 2D).
In subgroup analysis of the cause of death after propensity matching, the percentage of CV death was significant higher in AF cohort than in VTE cohort (VTE cohort versus AF cohort: 56.4% versus 66.6%, P<0.001). (Supplemental table 5) The percentages of death related to cancer and infection other than pneumonia among the causes of non-CV death were significantly higher in the VTE cohort than in the AF cohort.