Background:
Primary thyroid angiosarcoma (TAS) is the most common of the mesenchymal thyroid tumors, which are extremely rare and occur in a rate less than 1% [1], [2]. They show a high prevalence in Alpine areas, which is probably related to iodine deficiency in the areas and the presence of multinodular goiter [3], [4]. Additional predisposing factors are reported in the literature, such as exposure to radiation and vinyl chloride [5], [6]. It occurs mainly in adults 70 years of age, with a higher rate in women (4.5:1 ratio) [3]. The clinical manifestations of TAS are non-specific and vary depending on the location, size, extension and metastases. It generally presents as an invasive mass in the cervix causing symptoms of obstruction due to its rapid growth, such as shortness of breath, hoarseness and dysphagia. Fever, anemia and leukocytosis are often observed in the context of paraneoplastic syndrome [7]. TAS is an aggressive neoplasm with poor prognosis and resulting in death within 6-9 months due to premature metastases to lymph nodes, lungs, bones and soft molecules [8], [9]. TAS is reported to be a very rare entity, with a recent literature review recording 59 cases [8]. Herein we describe the 60th case of a 69-year-old female patient from Greece.