Receptor name Family (GRAFS) name Expression Function Signaling effectors (G or arrestin) References
ADGRG2(GPR64) Adhesion efferent ductules; proximal epididymis (non-ciliated cells; principal cells) fluid reabsorption Gs; Gq; β-arrestin-1 Davies et al., 2004; Gottwald et al., 2006; Zhang et al., 2018
AGTR2 Rhodopsin basal cells proton secretion unknown Shum et al., 2008
LGR4 (GPR48) Rhodopsin epithelial cells in the reproductive organs epithelial-mesenchymal interactions Gs Mendive et al., 2006; Gao et al., 2006; Li et al., 2010
GPER (GPR30) Rhodopsin testis; spermatozoa; prostate; efferent ductules; epididymis formation of blood-epididymal barrier and regulation of osmotic pressure Gs; β-arrestin-2 Katleba et al., 2015; Cao et al., 2017
Adenosine receptor Rhodopsin epididymis contractility of the epididymis Gs; Gi; β-arrestin Geldenhuys et al., 2017; Haynes et al., 1998b