Doxycycline does not affect the therapeutic effect of L-DOPA
The lesioned animals displayed akinesia of the contralateral forelimb (Fig. 1-C, stepping test) and a decrease in the distance traveled (Fig. 1-D, open-field test) demonstrating compromised motor ability. L-DOPA treatment improved akinesia and increased the distance traveled (Figs. 1-C and -D). Doxycycline did not improve motor function as revealed by the akinesia (Fig. 1-C, stepping test) and distance traveled (Fig. 1-D, open-field test).