TREATMENTS
LOCOMOTOR ACTIVITY (m) LOCOMOTOR ACTIVITY (m)
TIME OF IMMOBILITY (s)
ACUTE DOX ACUTE DOX ACUTE DOX ACUTE DOX
No-lesion+vehicle+vehicle
No-lesion+vehicle+vehicle
68.3 ± 2.3*
232.7 ± 12.1*
6-OHDA+vehicle+vehicle
6-OHDA+vehicle+vehicle
12.7 ± 1.4
387.3 ± 26.1
6-OHDA+doxycycline+vehicle
6-OHDA+doxycycline+vehicle
12.5 ± 1.7
395.4 ± 32.6
6-OHDA+vehicle+L-DOPA
6-OHDA+vehicle+L-DOPA
42.2 ± 4.9*
229.8 ± 16.2*
6-OHDA+doxycycline+L-DOPA
6-OHDA+doxycycline+L-DOPA
38.1 ± 4.0*
218.5 ± 29.5*
CHRONIC DOX CHRONIC DOX CHRONIC DOX CHRONIC DOX
No-lesion+chronic-vehicle+vehicle No-lesion+chronic-vehicle+vehicle 45.3 ± 4.2* 114.8 ± 13.1*
6-OHDA+chronic-vehicle+vehicle 6-OHDA+chronic-vehicle+vehicle 9.8 ± 1.6 349.4 ± 52.6
6-OHDA+chronic-doxycycline+vehicle 6-OHDA+chronic-doxycycline+vehicle 9.3 ± 1.8 472.3 ± 20.4
6-OHDA+chronic-vehicle+L-DOPA 6-OHDA+chronic-vehicle+L-DOPA 28.2 ± 3.9* 130.1 ± 50.3*
6-OHDA+chronic-doxycycline+L-DOPA 6-OHDA+chronic-doxycycline+L-DOPA 25.7 ± 5.4* 144.4 ± 42.2*
ACUTE COL-3 ACUTE COL-3 ACUTE COL-3 ACUTE COL-3
6-OHDA+vehicle+vehicle 6-OHDA+vehicle+vehicle 11.6 ± 7.1 315.1 ± 31.2
6-OHDA+COL-3+vehicle 6-OHDA+COL-3+vehicle 13.2 ± 5.1 303.4 ± 25.1
6-OHDA+vehicle+L-DOPA 6-OHDA+vehicle+L-DOPA 26.9 ± 3.8* 127 ± 13.2*
6-OHDA+COL-3+L-DOPA 6-OHDA+COL-3+L-DOPA 27.8 ± 4.4* 128 ± 16.4*