Carrying an autoinjector
It is unclear whether carrying an adrenaline autoinjector impacts on the perceived burden of care amongst people at risk of anaphylaxis because the certainty of evidence is very low (supplement S8a). One trial with people allergic to yellow jacket venom found that carrying an adrenaline autoinjector was associated with a 44% increase in the perceived burden of treatment compared to venom immunotherapy (statistically significant, CI not reported, very low certainty).11Oude Elberink JN, van der Heide S, Guyatt GH, Dubois AE. Analysis of the burden of treatment in patients receiving an EpiPen for yellow jacket anaphylaxis. J Allergy Clin Immunol 2006;118(3):699-704.
We did not identify any eligible studies assessing the most effective number of autoinjectors to prescribe.