Outcomes
Population
Absolute effect
Relative effect (95% CI)
Certainty of effect
Overall conclusion
Studies (participants)
Severe reactions within 1 hour of prophylactic adrenaline for snake bite anti-venom
Children and adults
43% reduction (p<0.05)
OR 0.57 (0.43 to 0.75)
Very Low
Unknown impact
1 trial (n = 1007) (de Silva 2011)
Severe reactions within 48 hours of prophylactic adrenaline for snake bite anti-venom
Children and adults
Range 8% to 38% reduction (p<0.05)
RR in one study 0 (0 to 1.3) OR in another study 0.62 (0.51 to 0.74)
Low
May reduce
2 trials (n = 1112) (Premawardhena 1999, de Silva 2011)
Severe reactions within 1 hour of prophylactic hydrocortisone for snake bite anti-venom
Children and adults
0.5% increase (p>0.05)
OR 0.86 (0.60 to 1.24)
Very low
Unknown impact
1 trial (n = 1007) (de Silva 2011)
Moderate and severe reactions within 48 hours of prophylactic hydrocortisone for snake bite anti-venom
Children and adults
23% reduction (p>0.05)
Not reported
Very Low
Unknown impact
1 trial (n = 52) (Gawarammana 2004)
Moderate and severe reactions within 48 hours of prophylactic hydrocortisone plus chlorpheniramine for snake bite anti-venom
Children and adults
23% reduction (p>0.05)
Not reported
Very low
Unknown impact
1 trial (n = 52) (Gawarammana 2004)
Severe reactions within 1 hour of prophylactic promethazine (antihistamine) for snake bite anti-venom
Children and adults
2.9% reduction (p>0.05)
OR 0.81 (0.51 to 1.30)
Very low
Unknown impact
1 trial (n = 1007) (de Silva 2011)
Anaphylactic reactions within 24 hours of prophylactic promethazine (antihistamine) for snake bite anti-venom
Children and adults
1% reduction (p>0.05)
Not reported
Very low
Unknown impact
1 trial (n = 101) (Fan 1999)