Study selection and data extraction
An information specialist/methodologist (CS) searched five databases using a search strategy developed with clinicians and patient representatives (see online supplement S1). Two methodologists identified additional references by searching the reference lists of previous reviews, guidelines and identified studies and seeking recommendations from experts (CS, DdS). Two methodologists independently screened titles and abstracts and the full text of any studies deemed potentially relevant (CS, DdS). Shortlisted studies were rescreened by all clinicians, allied health professionals and patient representatives on the task force (all authors). We excluded studies where it was unclear that the reactions described were anaphylaxis (see online supplement S2). There was 100% inter-rater agreement about the studies included.
Data about study characteristics and outcomes were extracted into a template independently by two methodologists (CS, DdS) and by task force members divided into small topic groups (all authors).