SARS-CoV-2 infection can enhance broad and non-specific immune
activation including hyperactivation of the complement[13].
Co-occurrence of SARS-CoV-2 infection may be an exacerbating factor and
may be the reason for the high rate of SARS-CoV-2 co-infection
Corticosteroids have been reported to be effective in the treatment of
liver injury with AAV vectors. Since all of the current candidate causes
are unlikely to be seriously aggravated by short-term corticosteroid
administration, a single, short-acting corticosteroid administration and
observation of response may be considered at an early stage of
diagnosis, given the risk of progression to severe hepatitis. AAV type 2
is difficult to test for in the general hospital setting, and guidelines
should be urgently developed for tests that should be performed on acute
hepatitis of unknown origin in children. Polymerase Chain Reaction
testing for AAV should be performed in both blood and stool, along with
adenovirus. In addition, analysis of AAV type 2 capsid-specific T cells
by ELISPOT in patients may be the key to elucidating the cause
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